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Preparation and characterisation of a sensing system for wireless pH measurements in vivo, in a rumen of a cow

Schanzenbach, Christoph; Ilver, Dag; Blomgren, Jakob; Jonasson, Christian; Johansson, Christer; Krozer, Anatol; Ye, Lei LU and Rustas, Bengt Ove (2017) In Sensors and Actuators, B: Chemical 242. p.637-644
Abstract

We describe a sensing system that is able to measure pH in-vivo, in the rumen of a cow, in real time. The sensing principle is based on gravimetric transduction using a magnetoelastic ribbon functionalized by pH-sensitive nanobeads that is placed in the rumen where it is actuated and read-out wirelessly. We describe a generic procedure that enables one to deposit monolayers or multilayers of nano- and micro beads onto virtually any substrate. The topography of the resulting layers as well as interlayer coverages were characterised using optical microscopy and scanning profilometry. First we determined performance of the system in-vitro, in phosphate-buffered saline, in McDougall's buffer and in a rumen fluid. Thereafter we also... (More)

We describe a sensing system that is able to measure pH in-vivo, in the rumen of a cow, in real time. The sensing principle is based on gravimetric transduction using a magnetoelastic ribbon functionalized by pH-sensitive nanobeads that is placed in the rumen where it is actuated and read-out wirelessly. We describe a generic procedure that enables one to deposit monolayers or multilayers of nano- and micro beads onto virtually any substrate. The topography of the resulting layers as well as interlayer coverages were characterised using optical microscopy and scanning profilometry. First we determined performance of the system in-vitro, in phosphate-buffered saline, in McDougall's buffer and in a rumen fluid. Thereafter we also performed in-vivo measurements. Using buffers we determined pH response in the liquids both at the fundamental frequency of the functionalised foils, and at the 1st overtone. We argue that observed frequency changes vs pH are mainly due to changes of trapped liquid when the bead layers shrink or expand as a response to changed pH. The data obtained from the pH response of magnetoelastic foils at different bead coverages was modelled by a simple two-parameter model that corroborates this assumption.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Layer-by-layer deposition, Magnetoelastic resonance, Mussel adhesive protein, Nanoparticle multilayers, pH sensitive polymer, Rumen pH
in
Sensors and Actuators, B: Chemical
volume
242
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:84998829105
  • wos:000393267700078
ISSN
0925-4005
DOI
10.1016/j.snb.2016.11.089
language
English
LU publication?
yes
id
fddc09bd-e074-4f29-a807-fc9ad7d96d8d
date added to LUP
2017-02-03 07:38:16
date last changed
2018-01-07 11:47:50
@article{fddc09bd-e074-4f29-a807-fc9ad7d96d8d,
  abstract     = {<p>We describe a sensing system that is able to measure pH in-vivo, in the rumen of a cow, in real time. The sensing principle is based on gravimetric transduction using a magnetoelastic ribbon functionalized by pH-sensitive nanobeads that is placed in the rumen where it is actuated and read-out wirelessly. We describe a generic procedure that enables one to deposit monolayers or multilayers of nano- and micro beads onto virtually any substrate. The topography of the resulting layers as well as interlayer coverages were characterised using optical microscopy and scanning profilometry. First we determined performance of the system in-vitro, in phosphate-buffered saline, in McDougall's buffer and in a rumen fluid. Thereafter we also performed in-vivo measurements. Using buffers we determined pH response in the liquids both at the fundamental frequency of the functionalised foils, and at the 1st overtone. We argue that observed frequency changes vs pH are mainly due to changes of trapped liquid when the bead layers shrink or expand as a response to changed pH. The data obtained from the pH response of magnetoelastic foils at different bead coverages was modelled by a simple two-parameter model that corroborates this assumption.</p>},
  author       = {Schanzenbach, Christoph and Ilver, Dag and Blomgren, Jakob and Jonasson, Christian and Johansson, Christer and Krozer, Anatol and Ye, Lei and Rustas, Bengt Ove},
  issn         = {0925-4005},
  keyword      = {Layer-by-layer deposition,Magnetoelastic resonance,Mussel adhesive protein,Nanoparticle multilayers,pH sensitive polymer,Rumen pH},
  language     = {eng},
  month        = {04},
  pages        = {637--644},
  publisher    = {Elsevier},
  series       = {Sensors and Actuators, B: Chemical},
  title        = {Preparation and characterisation of a sensing system for wireless pH measurements in vivo, in a rumen of a cow},
  url          = {http://dx.doi.org/10.1016/j.snb.2016.11.089},
  volume       = {242},
  year         = {2017},
}