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Blood pressure, body size and prostate cancer risk in the Swedish construction workers cohort

Stocks, Tanja LU ; Hergens, Maria Pia ; Englund, Anders ; Ye, Weimin and Stattin, Pär (2010) In International Journal of Cancer 127(7). p.1660-1668
Abstract

Data from prospective studies on blood pressure and prostate cancer risk are limited, and results are inconclusive. Baseline measurements of height, weight and blood pressure were available in 336,159 men in the Swedish Construction Workers cohort. During an average of 22.2 years of follow-up, 10,002 incident cases and 2,601 fatal cases of prostate cancer were identified in National registers. For 5,219 cases, tumor characteristics were available; 2,817 tumors were classified as nonaggressive and 2,402 as aggressive. Relative risks of disease were estimated from Cox regression models, using attained age as time-scale, and adjusting for birth year, smoking status and body mass index (BMI). Top compared to bottom quintile level of... (More)

Data from prospective studies on blood pressure and prostate cancer risk are limited, and results are inconclusive. Baseline measurements of height, weight and blood pressure were available in 336,159 men in the Swedish Construction Workers cohort. During an average of 22.2 years of follow-up, 10,002 incident cases and 2,601 fatal cases of prostate cancer were identified in National registers. For 5,219 cases, tumor characteristics were available; 2,817 tumors were classified as nonaggressive and 2,402 as aggressive. Relative risks of disease were estimated from Cox regression models, using attained age as time-scale, and adjusting for birth year, smoking status and body mass index (BMI). Top compared to bottom quintile level of systolic or diastolic blood pressure was associated with a significant 15-20% decreased risk of incident prostate cancer (p for trend: systolic < 0.0001, diastolic = 0.3), but blood pressure was not significantly associated with risk of fatal prostate cancer. BMI was not associated with prostate cancer incidence, but was positively associated with fatal prostate cancer; men in the top quintile had a 30% increased risk (p for trend = 0.0004). The associations between blood pressure and BMI and nonaggressive tumors were similar to those of incident prostate cancer, and associations with aggressive tumors were similar to those of fatal prostate cancer. Data from our study suggest that hypertension is associated with a decreased risk of incident prostate cancer, but the explanation for this finding is unclear. Our study support a positive association between overweight and risk of fatal prostate cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood pressure, Body size, Cohort studies, Overweight, Prostatic neoplasms
in
International Journal of Cancer
volume
127
issue
7
pages
9 pages
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:20087861
  • scopus:77956567266
ISSN
0020-7136
DOI
10.1002/ijc.25171
language
English
LU publication?
no
id
fdff2a20-f9a3-45b6-90d0-d720a16f9a6b
date added to LUP
2019-05-31 09:15:24
date last changed
2020-09-20 08:23:03
@article{fdff2a20-f9a3-45b6-90d0-d720a16f9a6b,
  abstract     = {<p>Data from prospective studies on blood pressure and prostate cancer risk are limited, and results are inconclusive. Baseline measurements of height, weight and blood pressure were available in 336,159 men in the Swedish Construction Workers cohort. During an average of 22.2 years of follow-up, 10,002 incident cases and 2,601 fatal cases of prostate cancer were identified in National registers. For 5,219 cases, tumor characteristics were available; 2,817 tumors were classified as nonaggressive and 2,402 as aggressive. Relative risks of disease were estimated from Cox regression models, using attained age as time-scale, and adjusting for birth year, smoking status and body mass index (BMI). Top compared to bottom quintile level of systolic or diastolic blood pressure was associated with a significant 15-20% decreased risk of incident prostate cancer (p for trend: systolic &lt; 0.0001, diastolic = 0.3), but blood pressure was not significantly associated with risk of fatal prostate cancer. BMI was not associated with prostate cancer incidence, but was positively associated with fatal prostate cancer; men in the top quintile had a 30% increased risk (p for trend = 0.0004). The associations between blood pressure and BMI and nonaggressive tumors were similar to those of incident prostate cancer, and associations with aggressive tumors were similar to those of fatal prostate cancer. Data from our study suggest that hypertension is associated with a decreased risk of incident prostate cancer, but the explanation for this finding is unclear. Our study support a positive association between overweight and risk of fatal prostate cancer.</p>},
  author       = {Stocks, Tanja and Hergens, Maria Pia and Englund, Anders and Ye, Weimin and Stattin, Pär},
  issn         = {0020-7136},
  language     = {eng},
  month        = {10},
  number       = {7},
  pages        = {1660--1668},
  publisher    = {John Wiley and Sons Inc.},
  series       = {International Journal of Cancer},
  title        = {Blood pressure, body size and prostate cancer risk in the Swedish construction workers cohort},
  url          = {http://dx.doi.org/10.1002/ijc.25171},
  doi          = {10.1002/ijc.25171},
  volume       = {127},
  year         = {2010},
}