GTPases of the prokaryotic translation apparatus
Hauryliuk, Vasili LU
(2006)
In Molecular Biology
40(5).
p.688-701
- Abstract
Bacterial protein synthesis involves four protein factors that belong to the GTPase family: IF2, EF-G, EF-Tu, and RF3. Their role in translation has attracted considerable interest over the recent decades. Cryoelectron microscopy has made it possible to monitor the dynamics of the ribosome upon binding of the translation factors, and biochemical findings have associated the structural data with functional changes in GTPases: the exchange of GDP for GTP, activation of GTPase, and changes in its conformation. The results have been used to construct models of GTPase action during prokaryotic translation. Data are accumulating that the ribosome simultaneously acts as a GDP/GTP exchange factor and a GTPase-activating factor for RF3, IF2, and... (More)
Bacterial protein synthesis involves four protein factors that belong to the GTPase family: IF2, EF-G, EF-Tu, and RF3. Their role in translation has attracted considerable interest over the recent decades. Cryoelectron microscopy has made it possible to monitor the dynamics of the ribosome upon binding of the translation factors, and biochemical findings have associated the structural data with functional changes in GTPases: the exchange of GDP for GTP, activation of GTPase, and changes in its conformation. The results have been used to construct models of GTPase action during prokaryotic translation. Data are accumulating that the ribosome simultaneously acts as a GDP/GTP exchange factor and a GTPase-activating factor for RF3, IF2, and EF-G. The review systematizes the most important experimental findings and theoretical models proposed for regulation of the functional cycle of prokaryotic translation GTPases.
(Less)
- author
- Hauryliuk, Vasili
LU
- publishing date
- 2006-10
- type
- Contribution to journal
- publication status
- published
- keywords
- EF-G, EF-Tu, GAP, GEF, GTPase, IF3, Prokaryotes, RF3, Ribosome, Translation
- in
- Molecular Biology
- volume
- 40
- issue
- 5
- pages
- 14 pages
- publisher
- Pleiades Publishing
- external identifiers
-
- scopus:33749857564
- ISSN
- 0026-8933
- DOI
- 10.1134/S0026893306050025
- language
- English
- LU publication?
- no
- additional info
- Copyright: Copyright 2009 Elsevier B.V., All rights reserved.
- id
- fe1a8bcd-9bc7-48cc-b54e-9c92cf8bc3c1
- date added to LUP
- 2021-09-24 20:53:01
- date last changed
- 2022-02-02 00:02:42
@article{fe1a8bcd-9bc7-48cc-b54e-9c92cf8bc3c1,
abstract = {{<p>Bacterial protein synthesis involves four protein factors that belong to the GTPase family: IF2, EF-G, EF-Tu, and RF3. Their role in translation has attracted considerable interest over the recent decades. Cryoelectron microscopy has made it possible to monitor the dynamics of the ribosome upon binding of the translation factors, and biochemical findings have associated the structural data with functional changes in GTPases: the exchange of GDP for GTP, activation of GTPase, and changes in its conformation. The results have been used to construct models of GTPase action during prokaryotic translation. Data are accumulating that the ribosome simultaneously acts as a GDP/GTP exchange factor and a GTPase-activating factor for RF3, IF2, and EF-G. The review systematizes the most important experimental findings and theoretical models proposed for regulation of the functional cycle of prokaryotic translation GTPases.</p>}},
author = {{Hauryliuk, Vasili}},
issn = {{0026-8933}},
keywords = {{EF-G; EF-Tu; GAP; GEF; GTPase; IF3; Prokaryotes; RF3; Ribosome; Translation}},
language = {{eng}},
number = {{5}},
pages = {{688--701}},
publisher = {{Pleiades Publishing}},
series = {{Molecular Biology}},
title = {{GTPases of the prokaryotic translation apparatus}},
url = {{http://dx.doi.org/10.1134/S0026893306050025}},
doi = {{10.1134/S0026893306050025}},
volume = {{40}},
year = {{2006}},
}