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Vaccines and allergic reactions : The past, the current COVID-19 pandemic, and future perspectives

Sampath, Vanitha ; Rabinowitz, Grace ; Shah, Mihir ; Jain, Surabhi ; Diamant, Zuzana LU ; Jesenak, Milos ; Rabin, Ronald ; Vieths, Stefan ; Agache, Ioana and Akdis, Mübeccel , et al. (2021) In Allergy: European Journal of Allergy and Clinical Immunology 76(6). p.1640-1660
Abstract

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the... (More)

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergy, anaphylaxis, COVID-19, SARS-CoV-2, vaccine
in
Allergy: European Journal of Allergy and Clinical Immunology
volume
76
issue
6
pages
21 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:33811364
  • scopus:85107119362
ISSN
0105-4538
DOI
10.1111/all.14840
language
English
LU publication?
yes
id
fe5d60c4-0c23-4bcc-a75f-3e2394ebc03d
date added to LUP
2021-07-12 12:06:03
date last changed
2024-06-29 14:28:11
@article{fe5d60c4-0c23-4bcc-a75f-3e2394ebc03d,
  abstract     = {{<p>Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.</p>}},
  author       = {{Sampath, Vanitha and Rabinowitz, Grace and Shah, Mihir and Jain, Surabhi and Diamant, Zuzana and Jesenak, Milos and Rabin, Ronald and Vieths, Stefan and Agache, Ioana and Akdis, Mübeccel and Barber, Domingo and Breiteneder, Heimo and Chinthrajah, Sharon and Chivato, Tomas and Collins, William and Eiwegger, Thomas and Fast, Katharine and Fokkens, Wytske and O'Hehir, Robyn E. and Ollert, Markus and O'Mahony, Liam and Palomares, Oscar and Pfaar, Oliver and Riggioni, Carmen and Shamji, Mohamed H. and Sokolowska, Milena and Jose Torres, Maria and Traidl-Hoffmann, Claudia and van Zelm, Menno and Wang, De Yun and Zhang, Luo and Akdis, Cezmi A. and Nadeau, Kari C.}},
  issn         = {{0105-4538}},
  keywords     = {{allergy; anaphylaxis; COVID-19; SARS-CoV-2; vaccine}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1640--1660}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Allergy: European Journal of Allergy and Clinical Immunology}},
  title        = {{Vaccines and allergic reactions : The past, the current COVID-19 pandemic, and future perspectives}},
  url          = {{http://dx.doi.org/10.1111/all.14840}},
  doi          = {{10.1111/all.14840}},
  volume       = {{76}},
  year         = {{2021}},
}