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The effect of diabetes on complications after distal pancreatectomy : A population-based cross-matched registry study

Bergenfeldt, Henrik LU ; Ekström, Eva LU ; Fagher, Katarina LU ; Filipsson, Karin LU and Andersson, Bodil LU orcid (2025) In Scandinavian Journal of Surgery
Abstract

Background: Distal pancreatic resection is associated with a high frequency of postoperative complications. The aim of this study was to characterize the effect of diabetes mellitus (DM) on short-term complications after distal pancreatectomy. Methods: Patients who underwent distal pancreatectomy between 1 January 2010 and 31 December 2020 were identified from the Swedish National Pancreatic and Periampullary Cancer Registry, and the data were cross-linked with the National Diabetes Registry. The complication rates were compared between patients with and without diabetes. Results: In total, 1297 patients underwent distal pancreatectomy, and 247 (19%) of these patients had DM. Postoperative complications occurred in 697/1297 (54%)... (More)

Background: Distal pancreatic resection is associated with a high frequency of postoperative complications. The aim of this study was to characterize the effect of diabetes mellitus (DM) on short-term complications after distal pancreatectomy. Methods: Patients who underwent distal pancreatectomy between 1 January 2010 and 31 December 2020 were identified from the Swedish National Pancreatic and Periampullary Cancer Registry, and the data were cross-linked with the National Diabetes Registry. The complication rates were compared between patients with and without diabetes. Results: In total, 1297 patients underwent distal pancreatectomy, and 247 (19%) of these patients had DM. Postoperative complications occurred in 697/1297 (54%) patients. There was no difference observed in the risk of overall complications (odds ratio (OR) = 0.76, 95% confidence interval [CI]: 0.58–1.00; p = 0.052), general surgical complications (p = 0.053), medical complications (p = 0.872), or postoperative pancreatic fistula rates (p = 0.603) according to the univariable analysis. In the multivariable analysis, patients with DM demonstrated a lower risk of overall complications (OR = 0.72, 95% CI = 0.54–0.96; p = 0.025). In the subgroup analysis, patients with high mean HbA1clevels (p = 0.041), high last measurement (p = 0.032), or DM duration >10 years (p = 0.022) exhibited lower risks of complications in the multivariable analysis. Conclusion: This study revealed a lower overall complication risk in patients with DM compared to patients without DM after distal pancreatectomy; however, no difference in the pancreatic fistula rate or medical complications was observed.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
diabetes mellitus, Distal pancreatectomy, hepatobiliary surgery, pancreatic cancer, pancreatic surgery, surgical complications
in
Scandinavian Journal of Surgery
publisher
Finnish Surgical Society
external identifiers
  • scopus:105021875071
  • pmid:41208312
ISSN
1457-4969
DOI
10.1177/14574969251390998
language
English
LU publication?
yes
id
fe645bb0-9bfe-41c4-bb87-b9c3dc599f87
date added to LUP
2026-02-10 14:09:24
date last changed
2026-02-11 03:00:07
@article{fe645bb0-9bfe-41c4-bb87-b9c3dc599f87,
  abstract     = {{<p>Background: Distal pancreatic resection is associated with a high frequency of postoperative complications. The aim of this study was to characterize the effect of diabetes mellitus (DM) on short-term complications after distal pancreatectomy. Methods: Patients who underwent distal pancreatectomy between 1 January 2010 and 31 December 2020 were identified from the Swedish National Pancreatic and Periampullary Cancer Registry, and the data were cross-linked with the National Diabetes Registry. The complication rates were compared between patients with and without diabetes. Results: In total, 1297 patients underwent distal pancreatectomy, and 247 (19%) of these patients had DM. Postoperative complications occurred in 697/1297 (54%) patients. There was no difference observed in the risk of overall complications (odds ratio (OR) = 0.76, 95% confidence interval [CI]: 0.58–1.00; p = 0.052), general surgical complications (p = 0.053), medical complications (p = 0.872), or postoperative pancreatic fistula rates (p = 0.603) according to the univariable analysis. In the multivariable analysis, patients with DM demonstrated a lower risk of overall complications (OR = 0.72, 95% CI = 0.54–0.96; p = 0.025). In the subgroup analysis, patients with high mean HbA<sub>1c</sub>levels (p = 0.041), high last measurement (p = 0.032), or DM duration &gt;10 years (p = 0.022) exhibited lower risks of complications in the multivariable analysis. Conclusion: This study revealed a lower overall complication risk in patients with DM compared to patients without DM after distal pancreatectomy; however, no difference in the pancreatic fistula rate or medical complications was observed.</p>}},
  author       = {{Bergenfeldt, Henrik and Ekström, Eva and Fagher, Katarina and Filipsson, Karin and Andersson, Bodil}},
  issn         = {{1457-4969}},
  keywords     = {{diabetes mellitus; Distal pancreatectomy; hepatobiliary surgery; pancreatic cancer; pancreatic surgery; surgical complications}},
  language     = {{eng}},
  publisher    = {{Finnish Surgical Society}},
  series       = {{Scandinavian Journal of Surgery}},
  title        = {{The effect of diabetes on complications after distal pancreatectomy : A population-based cross-matched registry study}},
  url          = {{http://dx.doi.org/10.1177/14574969251390998}},
  doi          = {{10.1177/14574969251390998}},
  year         = {{2025}},
}