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IFSI-Guideline on Chronic Prurigo including Prurigo nodularis.

Ständer, Sonja ; Pereira, Manuel P. ; Berger, T ; Zeidler, C ; Augustin, M ; Bobko, S. ; Brenaut, Emilie ; Chen, SC ; Chisolm, S and Dalgard, Florence J. , et al. (2020) In ITCH 5(4). p.1-13
Abstract
Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the development of an itch-scratch cycle contribute to the augmentation of pruritus and the chronicity of the disease. We provide here the first international guideline for a rational diagnostic and therapeutic approach for CPG. Recommendations are based on available evidence and expert opinion. The diagnosis of CPG is made clinically. A detailed medical history together with laboratory and radiological examinations are advised in order to determine the severity of CPG, identify the underlying origin of the... (More)
Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the development of an itch-scratch cycle contribute to the augmentation of pruritus and the chronicity of the disease. We provide here the first international guideline for a rational diagnostic and therapeutic approach for CPG. Recommendations are based on available evidence and expert opinion. The diagnosis of CPG is made clinically. A detailed medical history together with laboratory and radiological examinations are advised in order to determine the severity of CPG, identify the underlying origin of the itch and assist in the elaboration of a treatment plan. Therapeutically, it is advised to adopt a multimodal approach, including general strategies to control itch, treatment of the underlying pruritic conditions, and of the pruriginous lesions. Topical (corticosteroids, calcineurin inhibitors, capsaicin) and systemic antipruritic agents (eg, gabapentinoids, immunosuppressants, and opioid modulators) as well as physical treatment modalities (phototherapy, cryotherapy) should be employed in a step-wise approach. Psychosomatic or psychological interventions may be recommended in CPG patients with signs of psychiatric/psychological comorbidities. (Less)
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@article{fe6e471c-8305-4a0d-929c-ea8e58631e10,
  abstract     = {{Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the development of an itch-scratch cycle contribute to the augmentation of pruritus and the chronicity of the disease. We provide here the first international guideline for a rational diagnostic and therapeutic approach for CPG. Recommendations are based on available evidence and expert opinion. The diagnosis of CPG is made clinically. A detailed medical history together with laboratory and radiological examinations are advised in order to determine the severity of CPG, identify the underlying origin of the itch and assist in the elaboration of a treatment plan. Therapeutically, it is advised to adopt a multimodal approach, including general strategies to control itch, treatment of the underlying pruritic conditions, and of the pruriginous lesions. Topical (corticosteroids, calcineurin inhibitors, capsaicin) and systemic antipruritic agents (eg, gabapentinoids, immunosuppressants, and opioid modulators) as well as physical treatment modalities (phototherapy, cryotherapy) should be employed in a step-wise approach. Psychosomatic or psychological interventions may be recommended in CPG patients with signs of psychiatric/psychological comorbidities.}},
  author       = {{Ständer, Sonja and Pereira, Manuel P. and Berger, T and Zeidler, C and Augustin, M and Bobko, S. and Brenaut, Emilie and Chen, SC and Chisolm, S and Dalgard, Florence J. and Elberling, J. and Elmariah, SB and Evers, A W M and Garcovich, S and Goncalo, M and Halvorsen, Jon Anders and Kim, BS and Kupfer, Jörg and Kwatra S, S and Lambert, J and Legat, F J and Lerner, EA and Leslie, T. A. and Lönndahl, L and Lvov, A. and Metz, M. and Misery, Laurent and Papadavid, E and Potekaev, NN and Reich, A and Savk, E. and Schneider, Gunter and Schut, Christina and Serra-Baldrich, E and Ständer, H. F. and Streit, M and Szepietowski, Jacek C. and Tharp, MD and Wallengren, Joanna and Nast, A and Weisshaar, Elke and Yosipovitch, G}},
  issn         = {{2380-5048}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{4}},
  pages        = {{1--13}},
  publisher    = {{Wolters Kluwer}},
  series       = {{ITCH}},
  title        = {{IFSI-Guideline on Chronic Prurigo including Prurigo nodularis.}},
  url          = {{http://dx.doi.org/10.1097/itx.0000000000000042}},
  doi          = {{10.1097/itx.0000000000000042}},
  volume       = {{5}},
  year         = {{2020}},
}