Cell density dependent uptake of chylomicron remnants in rat hepatocyte monolaayers. Effects of compactin and mevalonic acid.
(1987) In Biochimica et Biophysica Acta 917(1). p.74-80- Abstract
- In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant uptake. Chylomicron remnant uptake in hepatocyte cultures can thus be influenced by factors known to regulate the apolipoprotein-BE receptor activity.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fe7d500d-cdbd-4fd8-ae43-208d6aed0835
- author
- Jensen, Elmo ; Florén, Claes-Henrik LU and Nilsson, Åke LU
- organization
- publishing date
- 1987-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochimica et Biophysica Acta
- volume
- 917
- issue
- 1
- pages
- 74 - 80
- publisher
- Elsevier
- external identifiers
-
- scopus:0023077347
- ISSN
- 0006-3002
- DOI
- 10.1016/0005-2760(87)90285-2
- language
- English
- LU publication?
- yes
- id
- fe7d500d-cdbd-4fd8-ae43-208d6aed0835
- date added to LUP
- 2019-05-30 17:00:54
- date last changed
- 2024-01-01 08:40:36
@article{fe7d500d-cdbd-4fd8-ae43-208d6aed0835, abstract = {{In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant uptake. Chylomicron remnant uptake in hepatocyte cultures can thus be influenced by factors known to regulate the apolipoprotein-BE receptor activity.}}, author = {{Jensen, Elmo and Florén, Claes-Henrik and Nilsson, Åke}}, issn = {{0006-3002}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{74--80}}, publisher = {{Elsevier}}, series = {{Biochimica et Biophysica Acta}}, title = {{Cell density dependent uptake of chylomicron remnants in rat hepatocyte monolaayers. Effects of compactin and mevalonic acid.}}, url = {{http://dx.doi.org/10.1016/0005-2760(87)90285-2}}, doi = {{10.1016/0005-2760(87)90285-2}}, volume = {{917}}, year = {{1987}}, }