Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cell density dependent uptake of chylomicron remnants in rat hepatocyte monolaayers. Effects of compactin and mevalonic acid.

Jensen, Elmo ; Florén, Claes-Henrik LU and Nilsson, Åke LU (1987) In Biochimica et Biophysica Acta 917(1). p.74-80
Abstract
In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant uptake. Chylomicron remnant uptake in hepatocyte cultures can thus be influenced by factors known to regulate the apolipoprotein-BE receptor activity.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochimica et Biophysica Acta
volume
917
issue
1
pages
74 - 80
publisher
Elsevier
external identifiers
  • scopus:0023077347
ISSN
0006-3002
DOI
10.1016/0005-2760(87)90285-2
language
English
LU publication?
yes
id
fe7d500d-cdbd-4fd8-ae43-208d6aed0835
date added to LUP
2019-05-30 17:00:54
date last changed
2025-10-14 09:12:31
@article{fe7d500d-cdbd-4fd8-ae43-208d6aed0835,
  abstract     = {{In rat hepatocytes cultured in lipoprotein-deficient serum, the uptake and degradation of chylomicron remnant cholesteryl ester per mg cell protein varies inversely with cell density. Compactin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, stimulates the uptake at all cell densities. Mevalonic acid, on the other hand, can suppress a significant part of the remnant uptake. Chylomicron remnant uptake in hepatocyte cultures can thus be influenced by factors known to regulate the apolipoprotein-BE receptor activity.}},
  author       = {{Jensen, Elmo and Florén, Claes-Henrik and Nilsson, Åke}},
  issn         = {{0006-3002}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{74--80}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta}},
  title        = {{Cell density dependent uptake of chylomicron remnants in rat hepatocyte monolaayers. Effects of compactin and mevalonic acid.}},
  url          = {{http://dx.doi.org/10.1016/0005-2760(87)90285-2}},
  doi          = {{10.1016/0005-2760(87)90285-2}},
  volume       = {{917}},
  year         = {{1987}},
}