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Review findings included diminished coronary flow reserve after surgery in children with congenital heart disease and inflammation

Pesonen, Erkki LU ; Liuba, Petru LU and Aburawi, Elhadi H. LU (2019) In Acta Paediatrica, International Journal of Paediatrics 108(2). p.218-223
Abstract

Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow... (More)

Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow reserve was diminished in patients with congenital heart disease and inflammation after surgery, with or without a cardiopulmonary bypass. Other findings discussed by this review relate to volume and pressure overload in acyanotic congenital heart disease, reduced myocardial perfusion and cyanotic congenital heart disease. Conclusion: We still have much to discover about paediatric patients with congenital heart disease and inflammatory diseases. Understanding the pathophysiology of coronary blood flow could help the postoperative treatment of such patients.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Congenital heart disease, Coronary blood flow, Coronary flow reserve, Doppler echocardiography, Endothelial cell dysfunction, Paediatric coronary flow
in
Acta Paediatrica, International Journal of Paediatrics
volume
108
issue
2
pages
218 - 223
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85056819732
ISSN
0803-5253
DOI
10.1111/apa.14613
language
English
LU publication?
yes
id
fe95d644-229e-4d32-88bf-f7d31d357cff
date added to LUP
2018-11-29 14:58:26
date last changed
2019-02-20 11:38:26
@article{fe95d644-229e-4d32-88bf-f7d31d357cff,
  abstract     = {<p>Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow reserve was diminished in patients with congenital heart disease and inflammation after surgery, with or without a cardiopulmonary bypass. Other findings discussed by this review relate to volume and pressure overload in acyanotic congenital heart disease, reduced myocardial perfusion and cyanotic congenital heart disease. Conclusion: We still have much to discover about paediatric patients with congenital heart disease and inflammatory diseases. Understanding the pathophysiology of coronary blood flow could help the postoperative treatment of such patients.</p>},
  author       = {Pesonen, Erkki and Liuba, Petru and Aburawi, Elhadi H.},
  issn         = {0803-5253},
  keyword      = {Congenital heart disease,Coronary blood flow,Coronary flow reserve,Doppler echocardiography,Endothelial cell dysfunction,Paediatric coronary flow},
  language     = {eng},
  number       = {2},
  pages        = {218--223},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Review findings included diminished coronary flow reserve after surgery in children with congenital heart disease and inflammation},
  url          = {http://dx.doi.org/10.1111/apa.14613},
  volume       = {108},
  year         = {2019},
}