Review findings included diminished coronary flow reserve after surgery in children with congenital heart disease and inflammation
(2019) In Acta Paediatrica, International Journal of Paediatrics 108(2). p.218-223- Abstract
Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow... (More)
Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow reserve was diminished in patients with congenital heart disease and inflammation after surgery, with or without a cardiopulmonary bypass. Other findings discussed by this review relate to volume and pressure overload in acyanotic congenital heart disease, reduced myocardial perfusion and cyanotic congenital heart disease. Conclusion: We still have much to discover about paediatric patients with congenital heart disease and inflammatory diseases. Understanding the pathophysiology of coronary blood flow could help the postoperative treatment of such patients.
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- author
- Pesonen, Erkki LU ; Liuba, Petru LU and Aburawi, Elhadi H. LU
- organization
- publishing date
- 2019-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Congenital heart disease, Coronary blood flow, Coronary flow reserve, Doppler echocardiography, Endothelial cell dysfunction, Paediatric coronary flow
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 108
- issue
- 2
- pages
- 218 - 223
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:30312493
- scopus:85056819732
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.14613
- language
- English
- LU publication?
- yes
- id
- fe95d644-229e-4d32-88bf-f7d31d357cff
- date added to LUP
- 2018-11-29 14:58:26
- date last changed
- 2024-03-02 13:28:27
@article{fe95d644-229e-4d32-88bf-f7d31d357cff,
abstract = {{<p>Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow reserve was diminished in patients with congenital heart disease and inflammation after surgery, with or without a cardiopulmonary bypass. Other findings discussed by this review relate to volume and pressure overload in acyanotic congenital heart disease, reduced myocardial perfusion and cyanotic congenital heart disease. Conclusion: We still have much to discover about paediatric patients with congenital heart disease and inflammatory diseases. Understanding the pathophysiology of coronary blood flow could help the postoperative treatment of such patients.</p>}},
author = {{Pesonen, Erkki and Liuba, Petru and Aburawi, Elhadi H.}},
issn = {{0803-5253}},
keywords = {{Congenital heart disease; Coronary blood flow; Coronary flow reserve; Doppler echocardiography; Endothelial cell dysfunction; Paediatric coronary flow}},
language = {{eng}},
number = {{2}},
pages = {{218--223}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Review findings included diminished coronary flow reserve after surgery in children with congenital heart disease and inflammation}},
url = {{http://dx.doi.org/10.1111/apa.14613}},
doi = {{10.1111/apa.14613}},
volume = {{108}},
year = {{2019}},
}