Anfall av gåshud visade sig vara anti-LGI-1-encefalit
(2020) In Läkartidningen 117.- Abstract
Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid... (More)
Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid long-term disability. This case report describes a man with episodes of goose bumps and mild confusion caused by anti-LGI-1 encephalitis.
(Less)
- author
- Johansson Lindgren, Jessica ; Esbjörnsson, Magnus LU ; Tüzün, Erdem ; van Westen, Danielle LU ; Baureder, Regina LU and Sahin, Gürdal LU
- organization
- alternative title
- Episodes with goose bumps caused by anti-LGI-1 encephalitis
- publishing date
- 2020-04-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 117
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:32293017
- scopus:85083410339
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- fec3121a-c856-4746-a512-6706c4510722
- alternative location
- https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/fallbeskrivning/2020/04/anfall-av-gashud-visade-sig-vara-anti-lgi-1-encefalit/
- date added to LUP
- 2020-05-25 12:49:46
- date last changed
- 2024-09-04 23:22:35
@article{fec3121a-c856-4746-a512-6706c4510722, abstract = {{<p>Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid long-term disability. This case report describes a man with episodes of goose bumps and mild confusion caused by anti-LGI-1 encephalitis.</p>}}, author = {{Johansson Lindgren, Jessica and Esbjörnsson, Magnus and Tüzün, Erdem and van Westen, Danielle and Baureder, Regina and Sahin, Gürdal}}, issn = {{0023-7205}}, language = {{swe}}, month = {{04}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Anfall av gåshud visade sig vara anti-LGI-1-encefalit}}, url = {{https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/fallbeskrivning/2020/04/anfall-av-gashud-visade-sig-vara-anti-lgi-1-encefalit/}}, volume = {{117}}, year = {{2020}}, }