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Anfall av gåshud visade sig vara anti-LGI-1-encefalit

Johansson Lindgren, Jessica ; Esbjörnsson, Magnus LU ; Tüzün, Erdem ; van Westen, Danielle LU orcid ; Baureder, Regina LU and Sahin, Gürdal LU orcid (2020) In Läkartidningen 117.
Abstract

Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid... (More)

Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid long-term disability. This case report describes a man with episodes of goose bumps and mild confusion caused by anti-LGI-1 encephalitis.

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author
; ; ; ; and
organization
alternative title
Episodes with goose bumps caused by anti-LGI-1 encephalitis
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
117
publisher
Swedish Medical Association
external identifiers
  • scopus:85083410339
  • pmid:32293017
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
fec3121a-c856-4746-a512-6706c4510722
alternative location
https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/fallbeskrivning/2020/04/anfall-av-gashud-visade-sig-vara-anti-lgi-1-encefalit/
date added to LUP
2020-05-25 12:49:46
date last changed
2024-04-03 08:11:08
@article{fec3121a-c856-4746-a512-6706c4510722,
  abstract     = {{<p>Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid long-term disability. This case report describes a man with episodes of goose bumps and mild confusion caused by anti-LGI-1 encephalitis.</p>}},
  author       = {{Johansson Lindgren, Jessica and Esbjörnsson, Magnus and Tüzün, Erdem and van Westen, Danielle and Baureder, Regina and Sahin, Gürdal}},
  issn         = {{0023-7205}},
  language     = {{swe}},
  month        = {{04}},
  publisher    = {{Swedish Medical Association}},
  series       = {{Läkartidningen}},
  title        = {{Anfall av gåshud visade sig vara anti-LGI-1-encefalit}},
  url          = {{https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/fallbeskrivning/2020/04/anfall-av-gashud-visade-sig-vara-anti-lgi-1-encefalit/}},
  volume       = {{117}},
  year         = {{2020}},
}