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EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations

Gear, Jonathan I. ; Cox, Maurice G. ; Gustafsson, Johan LU ; Gleisner, Katarina Sjögreen LU ; Murray, Iain ; Glatting, Gerhard ; Konijnenberg, Mark and Flux, Glenn D. (2018) In European Journal of Nuclear Medicine and Molecular Imaging 45(13). p.2456-2474
Abstract

A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are... (More)

A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dosimetry, Uncertainty analysis
in
European Journal of Nuclear Medicine and Molecular Imaging
volume
45
issue
13
pages
2456 - 2474
publisher
Springer
external identifiers
  • pmid:30218316
  • scopus:85053621289
ISSN
1619-7070
DOI
10.1007/s00259-018-4136-7
language
English
LU publication?
yes
id
fec5cb0e-2d1b-4c4f-869a-747645b5408b
date added to LUP
2018-10-24 12:07:13
date last changed
2020-01-22 07:17:22
@article{fec5cb0e-2d1b-4c4f-869a-747645b5408b,
  abstract     = {<p>A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example.</p>},
  author       = {Gear, Jonathan I. and Cox, Maurice G. and Gustafsson, Johan and Gleisner, Katarina Sjögreen and Murray, Iain and Glatting, Gerhard and Konijnenberg, Mark and Flux, Glenn D.},
  issn         = {1619-7070},
  language     = {eng},
  number       = {13},
  pages        = {2456--2474},
  publisher    = {Springer},
  series       = {European Journal of Nuclear Medicine and Molecular Imaging},
  title        = {EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations},
  url          = {http://dx.doi.org/10.1007/s00259-018-4136-7},
  doi          = {10.1007/s00259-018-4136-7},
  volume       = {45},
  year         = {2018},
}