Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics
Butler, Corwin R. ; Boychuk, Jeffery A. ; Pomerleau, Francois ; Alcala, Ramona ; Huettl, Peter ; Ai, Yi ; Jakobsson, Johan LU
; Whiteheart, Sidney W.
; Gerhardt, Greg A.
and Smith, Bret N.
, et al.
(2020)
In Epilepsy Research
159.
- Abstract
- Background
Genesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ff099260-acdb-47f8-a4b2-accb47adadb0
- author
- Butler, Corwin R.
; Boychuk, Jeffery A.
; Pomerleau, Francois
; Alcala, Ramona
; Huettl, Peter
; Ai, Yi
; Jakobsson, Johan
LU
; Whiteheart, Sidney W.
; Gerhardt, Greg A.
and Smith, Bret N.
, et al. (More)
- Butler, Corwin R.
; Boychuk, Jeffery A.
; Pomerleau, Francois
; Alcala, Ramona
; Huettl, Peter
; Ai, Yi
; Jakobsson, Johan
LU
; Whiteheart, Sidney W.
; Gerhardt, Greg A.
; Smith, Bret N.
and Slevin, John T
(Less)
- organization
- publishing date
- 2020-01-20
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Epilepsy Research
- volume
- 159
- article number
- 106244
- publisher
- Elsevier
- external identifiers
-
- pmid:31816591
- pmid:31816591
- scopus:85075920814
- ISSN
- 1872-6844
- DOI
- 10.1016/j.eplepsyres.2019.106244
- language
- English
- LU publication?
- yes
- id
- ff099260-acdb-47f8-a4b2-accb47adadb0
- alternative location
- https://www.sciencedirect.com/science/article/pii/S0920121119305078?dgcid=coauthor
- date added to LUP
- 2019-12-09 08:47:40
- date last changed
- 2022-05-04 02:46:57
@article{ff099260-acdb-47f8-a4b2-accb47adadb0,
abstract = {{Background<br/>Genesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).}},
author = {{Butler, Corwin R. and Boychuk, Jeffery A. and Pomerleau, Francois and Alcala, Ramona and Huettl, Peter and Ai, Yi and Jakobsson, Johan and Whiteheart, Sidney W. and Gerhardt, Greg A. and Smith, Bret N. and Slevin, John T}},
issn = {{1872-6844}},
language = {{eng}},
month = {{01}},
publisher = {{Elsevier}},
series = {{Epilepsy Research}},
title = {{Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics}},
url = {{http://dx.doi.org/10.1016/j.eplepsyres.2019.106244}},
doi = {{10.1016/j.eplepsyres.2019.106244}},
volume = {{159}},
year = {{2020}},
}