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Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors—A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)

Kenborg, Line ; Asdahl, Peter H. ; Bhatia, Smita ; Christensen, Jane ; Gudmundsdottir, Thorgerdur ; Hjorth, Lars LU ; Howell, Rebecca ; Krøyer, Anja ; Jørgensen, Morten and Laursen, Michael R.T. , et al. (2025) In Pediatric Blood and Cancer 72(8).
Abstract

The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9–33.7), abdominal radiation (4.8, 95% CI = 2.2–10.4), and cranial radiation (4.3, 95% CI = 2.1–8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and... (More)

The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9–33.7), abdominal radiation (4.8, 95% CI = 2.2–10.4), and cranial radiation (4.3, 95% CI = 2.1–8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and cranial radiation in CCS.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
childhood cancer survivors, diabetes, late effects, risk factors
in
Pediatric Blood and Cancer
volume
72
issue
8
article number
e31805
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:40399750
  • scopus:105005981049
ISSN
1545-5009
DOI
10.1002/pbc.31805
language
English
LU publication?
yes
id
ff31706f-70e1-4c21-b505-5df2e4a6fa1c
date added to LUP
2025-09-19 11:58:49
date last changed
2025-10-17 15:50:08
@article{ff31706f-70e1-4c21-b505-5df2e4a6fa1c,
  abstract     = {{<p>The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9–33.7), abdominal radiation (4.8, 95% CI = 2.2–10.4), and cranial radiation (4.3, 95% CI = 2.1–8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and cranial radiation in CCS.</p>}},
  author       = {{Kenborg, Line and Asdahl, Peter H. and Bhatia, Smita and Christensen, Jane and Gudmundsdottir, Thorgerdur and Hjorth, Lars and Howell, Rebecca and Krøyer, Anja and Jørgensen, Morten and Laursen, Michael R.T. and Lassen-Ramshad, Yasmin and de fine Licht, Sofie and Nielsen, Thomas Tjørnelund and Rechnitzer, Catherine and Smith, Susan A. and Wiebe, Thomas and Hasle, Henrik and Holmqvist, Anna S.}},
  issn         = {{1545-5009}},
  keywords     = {{childhood cancer survivors; diabetes; late effects; risk factors}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Pediatric Blood and Cancer}},
  title        = {{Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors—A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)}},
  url          = {{http://dx.doi.org/10.1002/pbc.31805}},
  doi          = {{10.1002/pbc.31805}},
  volume       = {{72}},
  year         = {{2025}},
}