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Dose-response effects of omega-3 on platelet aggregation: an observational study

KANDER, THOMAS LU orcid ; Lindblom, Erik and Schött, Ulf LU (2018) In Journal of International Medical Research 46(12). p.5074-5082
Abstract
Objective

This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.
Methods

Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.
Results

There were no differences in... (More)
Objective

This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.
Methods

Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.
Results

There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA .
Conclusions

Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of International Medical Research
volume
46
issue
12
pages
9 pages
publisher
SAGE Publications
external identifiers
  • pmid:30060687
  • scopus:85058659334
ISSN
1473-2300
DOI
10.1177/0300060518789817
language
English
LU publication?
yes
id
ff3853a2-f720-4df9-9738-31587eae6ac1
date added to LUP
2018-08-01 07:35:36
date last changed
2022-03-25 03:16:34
@article{ff3853a2-f720-4df9-9738-31587eae6ac1,
  abstract     = {{Objective<br/><br/>This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.<br/>Methods<br/><br/>Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.<br/>Results<br/><br/>There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA .<br/>Conclusions<br/><br/>Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA.}},
  author       = {{KANDER, THOMAS and Lindblom, Erik and Schött, Ulf}},
  issn         = {{1473-2300}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{12}},
  pages        = {{5074--5082}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of International Medical Research}},
  title        = {{Dose-response effects of omega-3 on platelet aggregation: an observational study}},
  url          = {{https://lup.lub.lu.se/search/files/48791937/0300060518789817.pdf}},
  doi          = {{10.1177/0300060518789817}},
  volume       = {{46}},
  year         = {{2018}},
}