Dose-response effects of omega-3 on platelet aggregation: an observational study
KANDER, THOMAS LU
; Lindblom, Erik
and Schött, Ulf
LU
(2018)
In Journal of International Medical Research
46(12).
p.5074-5082
- Abstract
- Objective
This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.
Methods
Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.
Results
There were no differences in... (More) - Objective
This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.
Methods
Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.
Results
There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA .
Conclusions
Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ff3853a2-f720-4df9-9738-31587eae6ac1
- author
- KANDER, THOMAS
LU
; Lindblom, Erik
and Schött, Ulf
LU
- organization
- publishing date
- 2018-07-30
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of International Medical Research
- volume
- 46
- issue
- 12
- pages
- 9 pages
- publisher
- SAGE Publications
- external identifiers
-
- pmid:30060687
- scopus:85058659334
- ISSN
- 1473-2300
- DOI
- 10.1177/0300060518789817
- language
- English
- LU publication?
- yes
- id
- ff3853a2-f720-4df9-9738-31587eae6ac1
- date added to LUP
- 2018-08-01 07:35:36
- date last changed
- 2025-10-14 11:55:15
@article{ff3853a2-f720-4df9-9738-31587eae6ac1,
abstract = {{Objective<br/><br/>This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.<br/>Methods<br/><br/>Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.<br/>Results<br/><br/>There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA .<br/>Conclusions<br/><br/>Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA.}},
author = {{KANDER, THOMAS and Lindblom, Erik and Schött, Ulf}},
issn = {{1473-2300}},
language = {{eng}},
month = {{07}},
number = {{12}},
pages = {{5074--5082}},
publisher = {{SAGE Publications}},
series = {{Journal of International Medical Research}},
title = {{Dose-response effects of omega-3 on platelet aggregation: an observational study}},
url = {{https://lup.lub.lu.se/search/files/48791937/0300060518789817.pdf}},
doi = {{10.1177/0300060518789817}},
volume = {{46}},
year = {{2018}},
}