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Mecanismo de participación de los Enterovirus en la neuropatía epidémica. Hipótesis fisiopatológicas

Más Lago, P ; Guzmán, M G ; Sarmiento Pérez, L LU ; Pérez, A B ; Alvarez, M ; Capó, V and Kourí, G (1997) In Revista cubana de medicina tropical 49(3). p.95-186
Abstract

During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to identify the cause of the epidemic. Taking into consideration the results of the different investigations, we have formulated a comprehensive and multifactorial hypothesis to explain the physiopathological mechanism of the participation of the isolated viruses as mediators in a process of autoimmunity of the pathogeny of the disease.

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author
; ; ; ; ; and
alternative title
Mechanism of Enterovirus participation in epidemic neuropathy. Physiopathological hypothesis
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Autoimmune Diseases/cerebrospinal fluid, Cerebrospinal Fluid/virology, Coxsackievirus Infections/complications, Cuba/epidemiology, Cytopathogenic Effect, Viral, Disease Outbreaks, Enterovirus/immunology, Humans, Interleukin-2/biosynthesis, Mice, Models, Biological, Molecular Mimicry, Nerve Tissue Proteins/immunology, Nutrition Disorders/complications, Optic Nerve Diseases/cerebrospinal fluid, Peripheral Nervous System Diseases/cerebrospinal fluid, Smoking/adverse effects, T-Lymphocyte Subsets/immunology, Viral Proteins/immunology, Virus Latency
in
Revista cubana de medicina tropical
volume
49
issue
3
pages
10 pages
publisher
Editorial Ciencias Medicas
external identifiers
  • scopus:0031310657
  • pmid:9685986
ISSN
0375-0760
language
Spanish
LU publication?
no
id
ff3d73a6-98e6-4947-a695-1c7de64849d3
alternative location
http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375-07601997000300006
date added to LUP
2019-07-08 15:39:55
date last changed
2024-01-01 15:48:37
@article{ff3d73a6-98e6-4947-a695-1c7de64849d3,
  abstract     = {{<p>During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to identify the cause of the epidemic. Taking into consideration the results of the different investigations, we have formulated a comprehensive and multifactorial hypothesis to explain the physiopathological mechanism of the participation of the isolated viruses as mediators in a process of autoimmunity of the pathogeny of the disease.</p>}},
  author       = {{Más Lago, P and Guzmán, M G and Sarmiento Pérez, L and Pérez, A B and Alvarez, M and Capó, V and Kourí, G}},
  issn         = {{0375-0760}},
  keywords     = {{Animals; Autoimmune Diseases/cerebrospinal fluid; Cerebrospinal Fluid/virology; Coxsackievirus Infections/complications; Cuba/epidemiology; Cytopathogenic Effect, Viral; Disease Outbreaks; Enterovirus/immunology; Humans; Interleukin-2/biosynthesis; Mice; Models, Biological; Molecular Mimicry; Nerve Tissue Proteins/immunology; Nutrition Disorders/complications; Optic Nerve Diseases/cerebrospinal fluid; Peripheral Nervous System Diseases/cerebrospinal fluid; Smoking/adverse effects; T-Lymphocyte Subsets/immunology; Viral Proteins/immunology; Virus Latency}},
  language     = {{spa}},
  number       = {{3}},
  pages        = {{95--186}},
  publisher    = {{Editorial Ciencias Medicas}},
  series       = {{Revista cubana de medicina tropical}},
  title        = {{Mecanismo de participación de los Enterovirus en la neuropatía epidémica. Hipótesis fisiopatológicas}},
  url          = {{http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375-07601997000300006}},
  volume       = {{49}},
  year         = {{1997}},
}