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Sick sinus syndrome and high-degree atrioventricular block in dementia with Lewy bodies and other dementia subtypes : A study of ≈ 73,000 patients with dementia

Heyman, Isak LU ; Haglund, Mattias LU ; Eriksdotter, Maria and Londos, Elisabet LU (2025) In Alzheimer's and Dementia: Translational Research and Clinical Interventions 11(1).
Abstract

INTRODUCTION: Lewy body pathology is commonly found in cardiac nervous tissue, including the cardiac conduction system. This study aimed to investigate the occurrence of sick sinus syndrome (SSS) and high-degree atrioventricular block in dementia with Lewy bodies (DLB) compared to Alzheimer's disease (AD) and other dementia subtypes.

METHODS: We included 73,619 individuals diagnosed with dementia from the Swedish Dementia Registry. Data pertaining to incident pacemaker implantation was obtained from the Swedish Pacemaker Registry.

RESULTS: SSS was more common in the DLB compared to the AD cohort (2.2% vs. 1.5%,
P = 0.008). In adjusted models, SSS was associated with DLB compared to AD (odds ratio, 1.49; 95% confidence... (More)

INTRODUCTION: Lewy body pathology is commonly found in cardiac nervous tissue, including the cardiac conduction system. This study aimed to investigate the occurrence of sick sinus syndrome (SSS) and high-degree atrioventricular block in dementia with Lewy bodies (DLB) compared to Alzheimer's disease (AD) and other dementia subtypes.

METHODS: We included 73,619 individuals diagnosed with dementia from the Swedish Dementia Registry. Data pertaining to incident pacemaker implantation was obtained from the Swedish Pacemaker Registry.

RESULTS: SSS was more common in the DLB compared to the AD cohort (2.2% vs. 1.5%,
P = 0.008). In adjusted models, SSS was associated with DLB compared to AD (odds ratio, 1.49; 95% confidence interval: 1.11-2.01).

DISCUSSION: We showed that incident pacemaker implantation secondary to SSS was more common in patients with DLB compared to those with AD.

HIGHLIGHTS: Incident pacemaker implantation secondary to sick sinus syndrome (SSS; but not high-degree atrioventricular block [HAVB]) was more common in dementia with Lewy bodies (DLB) versus Alzheimer's disease (AD).In adjusted models, SSS (but not HAVB) was positively associated with DLB compared to AD.Pacemaker data of various dementia disorders are presented.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's and Dementia: Translational Research and Clinical Interventions
volume
11
issue
1
article number
e70053
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85218974246
  • pmid:39975466
ISSN
2352-8737
DOI
10.1002/trc2.70053
language
English
LU publication?
yes
additional info
© 2025 The Author(s). Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
id
ff4c8314-08f9-4971-87e7-a35f61acf4ef
date added to LUP
2025-02-25 12:00:33
date last changed
2025-07-12 12:44:24
@article{ff4c8314-08f9-4971-87e7-a35f61acf4ef,
  abstract     = {{<p>INTRODUCTION: Lewy body pathology is commonly found in cardiac nervous tissue, including the cardiac conduction system. This study aimed to investigate the occurrence of sick sinus syndrome (SSS) and high-degree atrioventricular block in dementia with Lewy bodies (DLB) compared to Alzheimer's disease (AD) and other dementia subtypes.</p><p>METHODS: We included 73,619 individuals diagnosed with dementia from the Swedish Dementia Registry. Data pertaining to incident pacemaker implantation was obtained from the Swedish Pacemaker Registry.</p><p>RESULTS: SSS was more common in the DLB compared to the AD cohort (2.2% vs. 1.5%,<br>
 P = 0.008). In adjusted models, SSS was associated with DLB compared to AD (odds ratio, 1.49; 95% confidence interval: 1.11-2.01).<br>
 </p><p>DISCUSSION: We showed that incident pacemaker implantation secondary to SSS was more common in patients with DLB compared to those with AD.</p><p>HIGHLIGHTS: Incident pacemaker implantation secondary to sick sinus syndrome (SSS; but not high-degree atrioventricular block [HAVB]) was more common in dementia with Lewy bodies (DLB) versus Alzheimer's disease (AD).In adjusted models, SSS (but not HAVB) was positively associated with DLB compared to AD.Pacemaker data of various dementia disorders are presented.</p>}},
  author       = {{Heyman, Isak and Haglund, Mattias and Eriksdotter, Maria and Londos, Elisabet}},
  issn         = {{2352-8737}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Alzheimer's and Dementia: Translational Research and Clinical Interventions}},
  title        = {{Sick sinus syndrome and high-degree atrioventricular block in dementia with Lewy bodies and other dementia subtypes : A study of ≈ 73,000 patients with dementia}},
  url          = {{http://dx.doi.org/10.1002/trc2.70053}},
  doi          = {{10.1002/trc2.70053}},
  volume       = {{11}},
  year         = {{2025}},
}