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Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

Al-Jebari, Yahia LU ; Glimelius, Ingrid; Berglund Nord, C; Ståhl, Olof LU ; Tandstad, Torgrim; Jensen, Allan; Haugnes, Hege Sagstuen; Daugaard, Gedske; Rylander, Lars LU and Giwercman, Aleksander LU (2019) In PLoS Medicine 16(6).
Abstract
Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Medicine
volume
16
issue
6
publisher
Public Library of Science
external identifiers
  • scopus:85067425101
ISSN
1549-1676
DOI
10.1371/journal.pmed.1002816
language
English
LU publication?
yes
id
ff6e5991-81f2-452b-853d-dfdfe9cba170
alternative location
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002816
date added to LUP
2019-06-20 21:20:33
date last changed
2019-08-13 15:16:06
@article{ff6e5991-81f2-452b-853d-dfdfe9cba170,
  abstract     = {Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.},
  articleno    = {e1002816},
  author       = {Al-Jebari, Yahia and Glimelius, Ingrid and Berglund Nord, C and Ståhl, Olof and Tandstad, Torgrim and Jensen, Allan and Haugnes, Hege Sagstuen and Daugaard, Gedske and Rylander, Lars and Giwercman, Aleksander},
  issn         = {1549-1676},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS Medicine},
  title        = {Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study},
  url          = {http://dx.doi.org/10.1371/journal.pmed.1002816},
  volume       = {16},
  year         = {2019},
}