Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study
Al-Jebari, Yahia LU ; Glimelius, Ingrid ; Berglund Nord, C ; Ståhl, Olof LU ; Tandstad, Torgrim ; Jensen, Allan ; Haugnes, Hege Sagstuen ; Daugaard, Gedske ; Rylander, Lars LU
and Giwercman, Aleksander
LU
(2019)
In PLoS Medicine
16(6).
- Abstract
- Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ff6e5991-81f2-452b-853d-dfdfe9cba170
- author
- Al-Jebari, Yahia
LU
; Glimelius, Ingrid
; Berglund Nord, C
; Ståhl, Olof
LU
; Tandstad, Torgrim
; Jensen, Allan
; Haugnes, Hege Sagstuen
; Daugaard, Gedske
; Rylander, Lars
LU
and Giwercman, Aleksander
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Medicine
- volume
- 16
- issue
- 6
- article number
- e1002816
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:85067425101
- pmid:31163029
- ISSN
- 1549-1676
- DOI
- 10.1371/journal.pmed.1002816
- language
- English
- LU publication?
- yes
- id
- ff6e5991-81f2-452b-853d-dfdfe9cba170
- alternative location
- https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002816
- date added to LUP
- 2019-06-20 21:20:33
- date last changed
- 2024-01-31 00:30:33
@article{ff6e5991-81f2-452b-853d-dfdfe9cba170,
abstract = {{Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.}},
author = {{Al-Jebari, Yahia and Glimelius, Ingrid and Berglund Nord, C and Ståhl, Olof and Tandstad, Torgrim and Jensen, Allan and Haugnes, Hege Sagstuen and Daugaard, Gedske and Rylander, Lars and Giwercman, Aleksander}},
issn = {{1549-1676}},
language = {{eng}},
number = {{6}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS Medicine}},
title = {{Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study}},
url = {{http://dx.doi.org/10.1371/journal.pmed.1002816}},
doi = {{10.1371/journal.pmed.1002816}},
volume = {{16}},
year = {{2019}},
}