Alternative Time-Domain P-wave Analysis for Precise Information on Substrate Alteration after Pulmonary Vein Isolation for Atrial Fibrillation
(2021) 9th IEEE International Conference on E-Health and Bioengineering Conference, EHB 2021- Abstract
While P-wave duration (PWD) is primarily employed to observe the atrial substrate alterations after pulmonary vein isolation (PVI) on atrial fibrillation (AF) patients, the acquired information corresponds to the entire atria. Left (LA) and right atrium (RA), though, may be differently affected by PVI, implying the need for different after-PVI handling. In order to clarify this assumption, five-minute lead II recordings from 29 paroxysmal AF patients undergoing first-ever PVI were recruited before and after PVI. PWD was analyzed integrally and in parts, with the first part (PWD1) from the onset to the peak corresponding to RA and the second part (PWD2) to LA depolarization. Time from P-wave onset or offset to the R peak were also... (More)
While P-wave duration (PWD) is primarily employed to observe the atrial substrate alterations after pulmonary vein isolation (PVI) on atrial fibrillation (AF) patients, the acquired information corresponds to the entire atria. Left (LA) and right atrium (RA), though, may be differently affected by PVI, implying the need for different after-PVI handling. In order to clarify this assumption, five-minute lead II recordings from 29 paroxysmal AF patients undergoing first-ever PVI were recruited before and after PVI. PWD was analyzed integrally and in parts, with the first part (PWD1) from the onset to the peak corresponding to RA and the second part (PWD2) to LA depolarization. Time from P-wave onset or offset to the R peak were also calculated (Pon - R and Poff - R, respectively). Normalization (N) to mitigate heart-rate effect was applied. Results before and after PVI were compared with Mann-Whitney U-test (MWU). Median values and variations due to PVI were calculated for all features and compared between PWD and the remaining features via Pearson correlation. After PVI, PWD (-9.84%, p = 0.0085, N: - 17.96%, p = 0.0442) and PWD2 (-22.03%, p = 0.0250, N: - 27.77%, p = 0.0268) were significantly decreased. PWD1 did not shorten significantly (up to -8.96%, p > 0.05 at either cases). PWD - PWD1 (ρ > 74.5%, p < 0.0001) showed higher correlation than PWD - PWD2 (ρ > 41.9%, p < 0.0001) in before and after PVI analysis but not for PVI-related variation (ρPWD-PWD1 = 54.0%, p = 0.0114 and ρPWD-PWD2 = 61.4%, p = 0.0031). While RA depolarization time is more in line with PWD analysis, the effect of PVI in PWD is more coherent with LA's findings. Additionally, PWD shortening is only observed in the LA. Therefore, LA is crucial for the assessment of the atrial substrate alteration after PVI and its analysis should be considered by future studies.
(Less)
- author
- Vraka, Aikaterini ; Bertomeu-Gonzalez, Vicente ; Hornero, Fernando ; Sornmo, Leif LU ; Alcaraz, Raul and Rieta, Jose J.
- organization
- publishing date
- 2021
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Atrial fibrillation, left atrium, P-wave, partial analysis., pulmonary vein isolation
- host publication
- 2021 9th E-Health and Bioengineering Conference, EHB 2021
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- 9th IEEE International Conference on E-Health and Bioengineering Conference, EHB 2021
- conference location
- Iasi, Romania
- conference dates
- 2021-11-18 - 2021-11-19
- external identifiers
-
- scopus:85124503496
- ISBN
- 9781665440004
- DOI
- 10.1109/EHB52898.2021.9657541
- language
- English
- LU publication?
- yes
- id
- ff7262af-df3c-4332-bd38-6bf1f7dd8964
- date added to LUP
- 2022-04-12 10:17:50
- date last changed
- 2025-01-14 21:46:12
@inproceedings{ff7262af-df3c-4332-bd38-6bf1f7dd8964,
abstract = {{<p>While P-wave duration (PWD) is primarily employed to observe the atrial substrate alterations after pulmonary vein isolation (PVI) on atrial fibrillation (AF) patients, the acquired information corresponds to the entire atria. Left (LA) and right atrium (RA), though, may be differently affected by PVI, implying the need for different after-PVI handling. In order to clarify this assumption, five-minute lead II recordings from 29 paroxysmal AF patients undergoing first-ever PVI were recruited before and after PVI. PWD was analyzed integrally and in parts, with the first part (PWD1) from the onset to the peak corresponding to RA and the second part (PWD2) to LA depolarization. Time from P-wave onset or offset to the R peak were also calculated (Pon - R and Poff - R, respectively). Normalization (N) to mitigate heart-rate effect was applied. Results before and after PVI were compared with Mann-Whitney U-test (MWU). Median values and variations due to PVI were calculated for all features and compared between PWD and the remaining features via Pearson correlation. After PVI, PWD (-9.84%, p = 0.0085, N: - 17.96%, p = 0.0442) and PWD2 (-22.03%, p = 0.0250, N: - 27.77%, p = 0.0268) were significantly decreased. PWD1 did not shorten significantly (up to -8.96%, p > 0.05 at either cases). PWD - PWD1 (ρ > 74.5%, p < 0.0001) showed higher correlation than PWD - PWD2 (ρ > 41.9%, p < 0.0001) in before and after PVI analysis but not for PVI-related variation (ρPWD-PWD1 = 54.0%, p = 0.0114 and ρPWD-PWD2 = 61.4%, p = 0.0031). While RA depolarization time is more in line with PWD analysis, the effect of PVI in PWD is more coherent with LA's findings. Additionally, PWD shortening is only observed in the LA. Therefore, LA is crucial for the assessment of the atrial substrate alteration after PVI and its analysis should be considered by future studies. </p>}},
author = {{Vraka, Aikaterini and Bertomeu-Gonzalez, Vicente and Hornero, Fernando and Sornmo, Leif and Alcaraz, Raul and Rieta, Jose J.}},
booktitle = {{2021 9th E-Health and Bioengineering Conference, EHB 2021}},
isbn = {{9781665440004}},
keywords = {{Atrial fibrillation; left atrium; P-wave; partial analysis.; pulmonary vein isolation}},
language = {{eng}},
publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
title = {{Alternative Time-Domain P-wave Analysis for Precise Information on Substrate Alteration after Pulmonary Vein Isolation for Atrial Fibrillation}},
url = {{http://dx.doi.org/10.1109/EHB52898.2021.9657541}},
doi = {{10.1109/EHB52898.2021.9657541}},
year = {{2021}},
}