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First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

Schouenborg, J. LU and Sjölund, B. H. (1986) In Brain Research 379(2). p.394-398
Abstract

An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dorsal horn, glutamate, nociceptive primary afferent fibre, pain
in
Brain Research
volume
379
issue
2
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:0022508264
  • pmid:3742230
ISSN
0006-8993
DOI
10.1016/0006-8993(86)90798-5
language
English
LU publication?
yes
id
ff752667-95ff-4ee0-9fa5-96d7a5bf3206
date added to LUP
2019-06-25 16:09:30
date last changed
2020-08-02 06:50:22
@article{ff752667-95ff-4ee0-9fa5-96d7a5bf3206,
  abstract     = {<p>An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.</p>},
  author       = {Schouenborg, J. and Sjölund, B. H.},
  issn         = {0006-8993},
  language     = {eng},
  month        = {08},
  number       = {2},
  pages        = {394--398},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist},
  url          = {http://dx.doi.org/10.1016/0006-8993(86)90798-5},
  doi          = {10.1016/0006-8993(86)90798-5},
  volume       = {379},
  year         = {1986},
}