First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist
(1986) In Brain Research 379(2). p.394-398- Abstract
An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ff752667-95ff-4ee0-9fa5-96d7a5bf3206
- author
- Schouenborg, J. LU and Sjölund, B. H.
- organization
- publishing date
- 1986-08-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dorsal horn, glutamate, nociceptive primary afferent fibre, pain
- in
- Brain Research
- volume
- 379
- issue
- 2
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0022508264
- pmid:3742230
- ISSN
- 0006-8993
- DOI
- 10.1016/0006-8993(86)90798-5
- language
- English
- LU publication?
- yes
- id
- ff752667-95ff-4ee0-9fa5-96d7a5bf3206
- date added to LUP
- 2019-06-25 16:09:30
- date last changed
- 2024-01-01 13:12:36
@article{ff752667-95ff-4ee0-9fa5-96d7a5bf3206,
abstract = {{<p>An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.</p>}},
author = {{Schouenborg, J. and Sjölund, B. H.}},
issn = {{0006-8993}},
keywords = {{dorsal horn; glutamate; nociceptive primary afferent fibre; pain}},
language = {{eng}},
month = {{08}},
number = {{2}},
pages = {{394--398}},
publisher = {{Elsevier}},
series = {{Brain Research}},
title = {{First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist}},
url = {{http://dx.doi.org/10.1016/0006-8993(86)90798-5}},
doi = {{10.1016/0006-8993(86)90798-5}},
volume = {{379}},
year = {{1986}},
}