Decoding mechanical cues by molecular mechanotransduction
(2021) In Current Opinion in Cell Biology 72. p.72-80- Abstract
Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding magnitude and direction, and have distinct temporal profiles. Thus, the specific cellular response to mechanical forces is dependent on the ability of cells to sense and transduce these physical parameters. In this review, we will highlight recent findings that provide insights into the mechanisms by which different mechanosensors decode... (More)
Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding magnitude and direction, and have distinct temporal profiles. Thus, the specific cellular response to mechanical forces is dependent on the ability of cells to sense and transduce these physical parameters. In this review, we will highlight recent findings that provide insights into the mechanisms by which different mechanosensors decode mechanical cues and how their coordinated response determines the cellular outcomes.
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- author
- Swaminathan, Vinay LU and Gloerich, Martijn
- organization
- publishing date
- 2021-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Cell Biology
- volume
- 72
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:34218181
- scopus:85109430880
- ISSN
- 0955-0674
- DOI
- 10.1016/j.ceb.2021.05.006
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: The authors apologize to colleagues whose work could not be included because of space limitations. They thank Guillaume Jacquemet (University of Turku), Ben Goult (University of Kent), Pontus Nordenfelt (Lund University), and members of their laboratories for helpful discussions. This work was supported by Knut and Alice Wallenberg foundation (KAW, WCMM Lund) and the Netherlands Organization for Scientific Research (NWO; 016.Vidi.189.166 and NWO gravitational program CancerGenomiCs.nl).
- id
- ffb21069-4ff4-47ff-9005-bc5da5f648e0
- date added to LUP
- 2021-08-16 10:37:22
- date last changed
- 2024-04-20 10:23:19
@article{ffb21069-4ff4-47ff-9005-bc5da5f648e0,
abstract = {{<p>Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding magnitude and direction, and have distinct temporal profiles. Thus, the specific cellular response to mechanical forces is dependent on the ability of cells to sense and transduce these physical parameters. In this review, we will highlight recent findings that provide insights into the mechanisms by which different mechanosensors decode mechanical cues and how their coordinated response determines the cellular outcomes.</p>}},
author = {{Swaminathan, Vinay and Gloerich, Martijn}},
issn = {{0955-0674}},
language = {{eng}},
month = {{10}},
pages = {{72--80}},
publisher = {{Elsevier}},
series = {{Current Opinion in Cell Biology}},
title = {{Decoding mechanical cues by molecular mechanotransduction}},
url = {{http://dx.doi.org/10.1016/j.ceb.2021.05.006}},
doi = {{10.1016/j.ceb.2021.05.006}},
volume = {{72}},
year = {{2021}},
}