Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Immunity to gastrointestinal nematode infections

Sorobetea, D. LU ; Svensson-Frej, M. LU and Grencis, R. (2018) In Mucosal Immunology 11(2). p.304-315
Abstract

Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals and humans, with over a billion of the world's population infected with at least one species. These large multicellular pathogens present a considerable and complex challenge to the host immune system given that individuals are continually exposed to infective stages, as well as the high prevalence in endemic areas. This review summarizes our current understanding of host-parasite interactions, detailing induction of protective immunity, mechanisms of resistance, and resolution of the response. It is clear from studies of well-defined laboratory model systems that these responses are dominated by innate and adaptive type 2 cytokine responses,... (More)

Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals and humans, with over a billion of the world's population infected with at least one species. These large multicellular pathogens present a considerable and complex challenge to the host immune system given that individuals are continually exposed to infective stages, as well as the high prevalence in endemic areas. This review summarizes our current understanding of host-parasite interactions, detailing induction of protective immunity, mechanisms of resistance, and resolution of the response. It is clear from studies of well-defined laboratory model systems that these responses are dominated by innate and adaptive type 2 cytokine responses, regulating cellular and soluble effectors that serve to disrupt the niche in which the parasites live by strengthening the physical mucosal barrier and ultimately promoting tissue repair.

(Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mucosal Immunology
volume
11
issue
2
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85046068815
  • pmid:29297502
ISSN
1933-0219
DOI
10.1038/mi.2017.113
language
English
LU publication?
yes
id
ffd16cdf-14c5-43b2-bba5-439c280841ce
date added to LUP
2018-05-15 13:26:41
date last changed
2024-03-01 18:55:43
@article{ffd16cdf-14c5-43b2-bba5-439c280841ce,
  abstract     = {{<p>Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals and humans, with over a billion of the world's population infected with at least one species. These large multicellular pathogens present a considerable and complex challenge to the host immune system given that individuals are continually exposed to infective stages, as well as the high prevalence in endemic areas. This review summarizes our current understanding of host-parasite interactions, detailing induction of protective immunity, mechanisms of resistance, and resolution of the response. It is clear from studies of well-defined laboratory model systems that these responses are dominated by innate and adaptive type 2 cytokine responses, regulating cellular and soluble effectors that serve to disrupt the niche in which the parasites live by strengthening the physical mucosal barrier and ultimately promoting tissue repair.</p>}},
  author       = {{Sorobetea, D. and Svensson-Frej, M. and Grencis, R.}},
  issn         = {{1933-0219}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{2}},
  pages        = {{304--315}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Mucosal Immunology}},
  title        = {{Immunity to gastrointestinal nematode infections}},
  url          = {{http://dx.doi.org/10.1038/mi.2017.113}},
  doi          = {{10.1038/mi.2017.113}},
  volume       = {{11}},
  year         = {{2018}},
}