Advanced

Tumors of endocrine glands

Bullerdiek, Jörn and Gisselsson, David LU (2015) In Cancer Cytogenetics p.497-514
Abstract

Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in... (More)

Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in adrenocortical carcinomas. Clonal chromosome abnormalities have been reported in several thymomas, usually as part of near-diploid karyotypes as well as in a few thymic carcinomas. The use of comparative genomic hybridization (CGH)-based techniques may improve thymoma subtyping.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Adrenal gland, Chromosome banding, Comparative genomic hybridization, Endocrine pancreas, Malignant tumors, Neoplasms, Neuroblastoma, Parathyroid gland, Pituitary gland, Thyroid gland
in
Cancer Cytogenetics
editor
Heim, Sverre ; Mitelman, Felix; and
pages
18 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015843956
ISBN
9781118795569
9781118795538
DOI
10.1002/9781118795569.ch19
language
English
LU publication?
yes
id
fffa4206-61be-4744-bc46-f14736901bd9
date added to LUP
2017-04-20 10:49:32
date last changed
2017-04-20 10:49:32
@inbook{fffa4206-61be-4744-bc46-f14736901bd9,
  abstract     = {<p>Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in adrenocortical carcinomas. Clonal chromosome abnormalities have been reported in several thymomas, usually as part of near-diploid karyotypes as well as in a few thymic carcinomas. The use of comparative genomic hybridization (CGH)-based techniques may improve thymoma subtyping.</p>},
  author       = {Bullerdiek, Jörn and Gisselsson, David},
  editor       = {Heim, Sverre  and Mitelman, Felix},
  isbn         = {9781118795569},
  keyword      = {Adrenal gland,Chromosome banding,Comparative genomic hybridization,Endocrine pancreas,Malignant tumors,Neoplasms,Neuroblastoma,Parathyroid gland,Pituitary gland,Thyroid gland},
  language     = {eng},
  pages        = {497--514},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {Tumors of endocrine glands},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch19},
  year         = {2015},
}