Tumors of endocrine glands
(2015) p.497-514- Abstract
Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in... (More)
Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in adrenocortical carcinomas. Clonal chromosome abnormalities have been reported in several thymomas, usually as part of near-diploid karyotypes as well as in a few thymic carcinomas. The use of comparative genomic hybridization (CGH)-based techniques may improve thymoma subtyping.
(Less)
- author
- Bullerdiek, Jörn and Gisselsson, David LU
- organization
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Adrenal gland, Chromosome banding, Comparative genomic hybridization, Endocrine pancreas, Malignant tumors, Neoplasms, Neuroblastoma, Parathyroid gland, Pituitary gland, Thyroid gland
- host publication
- Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells - Chromosomal and Molecular Genetic Aberrations of Tumor Cells
- editor
- Heim, Sverre and Mitelman, Felix
- edition
- 4th
- pages
- 18 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85015843956
- ISBN
- 9781118795569
- 9781118795538
- DOI
- 10.1002/9781118795569.ch19
- language
- English
- LU publication?
- yes
- id
- fffa4206-61be-4744-bc46-f14736901bd9
- date added to LUP
- 2017-04-20 10:49:32
- date last changed
- 2024-01-13 19:18:54
@inbook{fffa4206-61be-4744-bc46-f14736901bd9, abstract = {{<p>Cytogenetic information is available on roughly 600 neoplasms originating from the thyroid, parathyroid, pituitary, and adrenal glands; from the thymus; and from the endocrine pancreas. Trisomy 7 is found in 30% of adenomas with clonal cytogenetic aberrations. In both the benign and malignant tumors, a combination of gains of or from chromosomes 5, 7, 12, 17, 19, and 20 was observed. Almost all pituitary tumors arise from the adenohypophysis and are benign adenomas; carcinomas are very rare. The clinical heterogeneity of Neuroblastoma (NB) is well reflected by its cytogenetic and genomic features. Clonal chromosome abnormalities were reported in adrenocortical adenomas. Chromosome banding studies have detected cytogenetic aberrations in adrenocortical carcinomas. Clonal chromosome abnormalities have been reported in several thymomas, usually as part of near-diploid karyotypes as well as in a few thymic carcinomas. The use of comparative genomic hybridization (CGH)-based techniques may improve thymoma subtyping.</p>}}, author = {{Bullerdiek, Jörn and Gisselsson, David}}, booktitle = {{Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells}}, editor = {{Heim, Sverre and Mitelman, Felix}}, isbn = {{9781118795569}}, keywords = {{Adrenal gland; Chromosome banding; Comparative genomic hybridization; Endocrine pancreas; Malignant tumors; Neoplasms; Neuroblastoma; Parathyroid gland; Pituitary gland; Thyroid gland}}, language = {{eng}}, pages = {{497--514}}, publisher = {{Wiley-Blackwell}}, title = {{Tumors of endocrine glands}}, url = {{http://dx.doi.org/10.1002/9781118795569.ch19}}, doi = {{10.1002/9781118795569.ch19}}, year = {{2015}}, }