Sesquiterpene lactones from Eupatorium lasiophtalmum
(2012) KEMR11 20121Department of Chemistry
- Abstract
- An investigation of Eupatorium lasiophthalmum yielded fourteen sesquiterpene lactones (1-14) including one new epimer (7) and a revision of the reported stereochemistry of 2 is suggested. One known sesquiterpene (15) and one triterpene (16) with a novel skeleton were found. Two known flavonoids (17-18) were also isolated. Michael adducts were prepared out of 1, 4 and 5 and their reversibility studied. The isolates 1-5, 7, 9, 15 and a cysteine ester adduct (19) were subjected to biological test to determine cytotoxicity against five different breast cancer cell lines. The adduct 19 showed significantly less cytotoxic efficacy compared to the sesquiterpene lactones. The anti-inflammatory activity of 4 was evaluated on LPS stimulated human... (More)
- An investigation of Eupatorium lasiophthalmum yielded fourteen sesquiterpene lactones (1-14) including one new epimer (7) and a revision of the reported stereochemistry of 2 is suggested. One known sesquiterpene (15) and one triterpene (16) with a novel skeleton were found. Two known flavonoids (17-18) were also isolated. Michael adducts were prepared out of 1, 4 and 5 and their reversibility studied. The isolates 1-5, 7, 9, 15 and a cysteine ester adduct (19) were subjected to biological test to determine cytotoxicity against five different breast cancer cell lines. The adduct 19 showed significantly less cytotoxic efficacy compared to the sesquiterpene lactones. The anti-inflammatory activity of 4 was evaluated on LPS stimulated human monocytes. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/3053563
- author
- Svensson, Daniel LU
- supervisor
- organization
- course
- KEMR11 20121
- year
- 2012
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Organisk kemi
- language
- English
- id
- 3053563
- date added to LUP
- 2012-09-19 11:29:35
- date last changed
- 2012-09-19 11:29:35
@misc{3053563, abstract = {{An investigation of Eupatorium lasiophthalmum yielded fourteen sesquiterpene lactones (1-14) including one new epimer (7) and a revision of the reported stereochemistry of 2 is suggested. One known sesquiterpene (15) and one triterpene (16) with a novel skeleton were found. Two known flavonoids (17-18) were also isolated. Michael adducts were prepared out of 1, 4 and 5 and their reversibility studied. The isolates 1-5, 7, 9, 15 and a cysteine ester adduct (19) were subjected to biological test to determine cytotoxicity against five different breast cancer cell lines. The adduct 19 showed significantly less cytotoxic efficacy compared to the sesquiterpene lactones. The anti-inflammatory activity of 4 was evaluated on LPS stimulated human monocytes.}}, author = {{Svensson, Daniel}}, language = {{eng}}, note = {{Student Paper}}, title = {{Sesquiterpene lactones from Eupatorium lasiophtalmum}}, year = {{2012}}, }