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Towards the synthesis of imageable salinomycin analogs

Kruszyk, Monika LU (2014) KEMP31 20141
Department of Chemistry
Abstract
Abstract is attached at the heading Related Materials.
Popular Abstract
According to the World Health Organization (WHO), cancer is the second most common cause of death worldwide, accounting for more than 8 million deaths. The number of diagnosed cases is expected to increase from 14 million (in 2012) to 22 million annually in 20 years.

Resistance to chemotherapy, cancer recurrence and metastasis are common clinical problems for patients suffering from cancer. A hypothesis is that these are caused by a small population of cells within a tumor, so-called cancer stem cells (CSCs) which are also believed to drive tumorigenesis. Current anticancer therapies are based on their ability to shrink tumors, leaving the population of CSCs largely untouched. This means that such therapies may fail, because they leave... (More)
According to the World Health Organization (WHO), cancer is the second most common cause of death worldwide, accounting for more than 8 million deaths. The number of diagnosed cases is expected to increase from 14 million (in 2012) to 22 million annually in 20 years.

Resistance to chemotherapy, cancer recurrence and metastasis are common clinical problems for patients suffering from cancer. A hypothesis is that these are caused by a small population of cells within a tumor, so-called cancer stem cells (CSCs) which are also believed to drive tumorigenesis. Current anticancer therapies are based on their ability to shrink tumors, leaving the population of CSCs largely untouched. This means that such therapies may fail, because they leave the cells that can regenerate and spread the tumor. Novel anticancer therapies aim to target also CSCs. Combined with currently used drugs such treatments could lead to cancer regression.

Studies performed in 2009 by Gupta and co-workers showed that salinomycin, a polyether antibiotic commonly used in veterinary medicine, was the most efficient out of 16000 compounds to decrease the population of cells with stem-like properties. The mechanism of action for this compound still remains unknown. We aimed towards the attachment of a suitable fluorescent probe to the salinomycin core structure, which would result in a new derivative that is visible in fluorescence microscopes. This would allow localizing SA in
cells and would provide useful information in explaining the molecular mode of action of SA against CSCs. (Less)
Please use this url to cite or link to this publication:
author
Kruszyk, Monika LU
supervisor
organization
course
KEMP31 20141
year
type
H2 - Master's Degree (Two Years)
subject
keywords
organisk kemi, organic chemistry
language
English
id
4780405
date added to LUP
2014-11-18 15:40:49
date last changed
2014-11-18 15:40:49
@misc{4780405,
  abstract     = {{Abstract is attached at the heading Related Materials.}},
  author       = {{Kruszyk, Monika}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Towards the synthesis of imageable salinomycin analogs}},
  year         = {{2014}},
}