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Neurotransmitter MIPs for the Potential Use in Amperometric Sensors

Rüter, Axel LU (2015) KBK820 20151
Pure and Applied Biochemistry
Abstract
Molecular imprinting technology is a field where polymer technology is
utilised to synthesise high affinity particles, much like antibodies. This
project has dealt with the imprinting of the neurotransmitter molecules serotonin
and histamine. Serotonin polymers were synthesised using methacrylic
acid and acrylamide as functional monomers relying on hydrogen bonding
for the imprinting effect. None of the produced batches showed any sign of
imprinting. Instead histamine polymers were successfully synthesised showing
specific binding with the average binding affinity Kd = 0:61 mM and the
approximate number of binding sites N = 50 μmolg
Popular Abstract
The common ways of measuring different analyte concentrations in the human blood are often based on antibodies. These biomolecules possess the best chemical recognition known and can easily distinguish friend from foe. Their perfection does however come at a very high price. Molecularly imprinted polymers (MIP) are a way around this. Easily chemically produced and much cheaper, these artifical antibodies can be incorporated in simple electrochemical devices for fast and precise concentration measurements, hopefully revolutionising the field of medical analysis.
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author
Rüter, Axel LU
supervisor
organization
course
KBK820 20151
year
type
H2 - Master's Degree (Two Years)
subject
keywords
serotonin, histamine, imprinting, neurotransmitter, MIP, sensor, voltammetry, applied biochemistry
language
English
id
7766479
date added to LUP
2015-09-07 09:50:37
date last changed
2015-09-07 09:50:37
@misc{7766479,
  abstract     = {Molecular imprinting technology is a field where polymer technology is
utilised to synthesise high affinity particles, much like antibodies. This
project has dealt with the imprinting of the neurotransmitter molecules serotonin
and histamine. Serotonin polymers were synthesised using methacrylic
acid and acrylamide as functional monomers relying on hydrogen bonding
for the imprinting effect. None of the produced batches showed any sign of
imprinting. Instead histamine polymers were successfully synthesised showing
specific binding with the average binding affinity Kd = 0:61 mM and the
approximate number of binding sites N = 50 μmolg},
  author       = {Rüter, Axel},
  keyword      = {serotonin,histamine,imprinting,neurotransmitter,MIP,sensor,voltammetry,applied biochemistry},
  language     = {eng},
  note         = {Student Paper},
  title        = {Neurotransmitter MIPs for the Potential Use in Amperometric Sensors},
  year         = {2015},
}