Neurotransmitter MIPs for the Potential Use in Amperometric Sensors
(2015) KBK820 20151Pure and Applied Biochemistry
- Abstract
- Molecular imprinting technology is a field where polymer technology is
utilised to synthesise high affinity particles, much like antibodies. This
project has dealt with the imprinting of the neurotransmitter molecules serotonin
and histamine. Serotonin polymers were synthesised using methacrylic
acid and acrylamide as functional monomers relying on hydrogen bonding
for the imprinting effect. None of the produced batches showed any sign of
imprinting. Instead histamine polymers were successfully synthesised showing
specific binding with the average binding affinity Kd = 0:61 mM and the
approximate number of binding sites N = 50 μmolg - Popular Abstract
- The common ways of measuring different analyte concentrations in the human blood are often based on antibodies. These biomolecules possess the best chemical recognition known and can easily distinguish friend from foe. Their perfection does however come at a very high price. Molecularly imprinted polymers (MIP) are a way around this. Easily chemically produced and much cheaper, these artifical antibodies can be incorporated in simple electrochemical devices for fast and precise concentration measurements, hopefully revolutionising the field of medical analysis.
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/7766479
- author
- Rüter, Axel LU
- supervisor
-
- Lei Ye LU
- organization
- course
- KBK820 20151
- year
- 2015
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- serotonin, histamine, imprinting, neurotransmitter, MIP, sensor, voltammetry, applied biochemistry
- language
- English
- id
- 7766479
- date added to LUP
- 2015-09-07 09:50:37
- date last changed
- 2015-09-07 09:50:37
@misc{7766479, abstract = {{Molecular imprinting technology is a field where polymer technology is utilised to synthesise high affinity particles, much like antibodies. This project has dealt with the imprinting of the neurotransmitter molecules serotonin and histamine. Serotonin polymers were synthesised using methacrylic acid and acrylamide as functional monomers relying on hydrogen bonding for the imprinting effect. None of the produced batches showed any sign of imprinting. Instead histamine polymers were successfully synthesised showing specific binding with the average binding affinity Kd = 0:61 mM and the approximate number of binding sites N = 50 μmolg}}, author = {{Rüter, Axel}}, language = {{eng}}, note = {{Student Paper}}, title = {{Neurotransmitter MIPs for the Potential Use in Amperometric Sensors}}, year = {{2015}}, }