Advanced

A review on ozonation and17a-ethinylestradiol - formation and effects in the environment of the by-products

Svensson, Erica LU (2017) MVEM12 20171
Studies in Environmental Science
Abstract
Today, waste water treatment plants do not remove pharmaceutical residues from the water (as there are currently no regulations for wastewater treatment in regards to pharmaceuticals residues in Sweden) resulting in a high concentration of pharmaceuticals reaching the environment. The Swedish environmental protection agency have recently concluded that there is a need for advanced treatment of pharmaceuticals in wastewater. One of the most promising techniques is ozonation however, the process can generate ecotoxic by-products. This study provides an overview of the current knowledge of by-products of 17α-ethinylestradiol (EE2), generated during the ozonation process. Special emphasis is on showing if by-products are produced in the... (More)
Today, waste water treatment plants do not remove pharmaceutical residues from the water (as there are currently no regulations for wastewater treatment in regards to pharmaceuticals residues in Sweden) resulting in a high concentration of pharmaceuticals reaching the environment. The Swedish environmental protection agency have recently concluded that there is a need for advanced treatment of pharmaceuticals in wastewater. One of the most promising techniques is ozonation however, the process can generate ecotoxic by-products. This study provides an overview of the current knowledge of by-products of 17α-ethinylestradiol (EE2), generated during the ozonation process. Special emphasis is on showing if by-products are produced in the ozonation process when removing EE2 and in what concentrations. Additionally, whether the by-products have an ecotoxicological effect on the environment and if there are any measured that can be taken to reduce the production of by-products. Method used to conduct this study was a systematic search over five databases and one search engine.
This study shows that by-products of EE2 are generated during ozonation. However, the results shows that there is a huge gap in knowledge, in regards to the amount of by-products created and in what concentration also their ecotoxcity and possible risk to the environment are mostly unknown. Some by-products have estrogenic activity and have shown to have detrimental effect on fetal rats testosterone secretion. This study shows therefore possible post ozonation treatment steps that could be implemented to reduce the potential toxicity of by-products reaching the environment. The knowledges gap needs to be corrected with future studies, as ozonation is one of the most likely treatment techniques for pharmaceuticals to be implemented in the future. (Less)
Popular Abstract (Swedish)
I dag finns det ingen läkemedelsrening i svenska reningsverk, eftersom det för närvarande inte finns några regler för avloppsrening av läkemedelsrester i Sverige, vilket resulterar i höga halter av läkemedelsrester i miljön. Naturvårdsverket drog, i en nyligen publicerad rapport, slutsatsen att det finns behov av avancerad behandling av läkemedel i avloppsvatten. En av de mest lovande läkemedelsreningsteknikerna är ozonering, men processen kan generera toxiska biprodukter. Denna studie ger en översikt över den nuvarande kunskapen om biprodukter av 17a-etinylestradiol (EE2), det aktiva ämnet i majoriteten av preventivmedel, som genereras under ozoneringsprocessen. Särskild vikt läggs vid att visa om biprodukter genereras i... (More)
I dag finns det ingen läkemedelsrening i svenska reningsverk, eftersom det för närvarande inte finns några regler för avloppsrening av läkemedelsrester i Sverige, vilket resulterar i höga halter av läkemedelsrester i miljön. Naturvårdsverket drog, i en nyligen publicerad rapport, slutsatsen att det finns behov av avancerad behandling av läkemedel i avloppsvatten. En av de mest lovande läkemedelsreningsteknikerna är ozonering, men processen kan generera toxiska biprodukter. Denna studie ger en översikt över den nuvarande kunskapen om biprodukter av 17a-etinylestradiol (EE2), det aktiva ämnet i majoriteten av preventivmedel, som genereras under ozoneringsprocessen. Särskild vikt läggs vid att visa om biprodukter genereras i ozoneringsprocessen vid avlägsnande av EE2 och i vilka koncentrationer. Dessutom, om biprodukterna har en toxisk effekt på miljön och om det finns några mätningar som kan vidtas för att minska produktionen av biprodukter. Metod som används för att genomföra denna studie var en systematisk sökning över fem databaser och en sökmotor. Denna studie visar att biprodukter av EE2 genereras under ozonering. Resultaten visar emellertid att det finns ett stort kunskapshål då mycket är okänt, speciellt med avseende på mängden biprodukter som skapas och i vilken koncentration, samt vilken toxicitet och möjlig risk för miljön. Vissa biprodukter har fortfarande östrogen aktivitet och har visat sig ha skadlig effekt på testosteronsekretionen hos råttor. Denna studie presenterar därför möjliga efterbehandlingssteg som skulle kunna genomföras för att minska den potentiella toxiciteten hos biprodukter som når miljön. Kunskapsklyftan måste korrigeras med framtida studier, eftersom ozonering är en av de mest lovande behandlingsteknikerna för läkemedel som kan implementeras i framtiden. (Less)
Please use this url to cite or link to this publication:
author
Svensson, Erica LU
supervisor
organization
course
MVEM12 20171
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Ethinylestradiol, EE2, By-products, Ozonation products, Transformation products, Ozonation
language
English
id
8912323
date added to LUP
2017-06-12 22:07:45
date last changed
2017-06-12 22:07:45
@misc{8912323,
  abstract     = {Today, waste water treatment plants do not remove pharmaceutical residues from the water (as there are currently no regulations for wastewater treatment in regards to pharmaceuticals residues in Sweden) resulting in a high concentration of pharmaceuticals reaching the environment. The Swedish environmental protection agency have recently concluded that there is a need for advanced treatment of pharmaceuticals in wastewater. One of the most promising techniques is ozonation however, the process can generate ecotoxic by-products. This study provides an overview of the current knowledge of by-products of 17α-ethinylestradiol (EE2), generated during the ozonation process. Special emphasis is on showing if by-products are produced in the ozonation process when removing EE2 and in what concentrations. Additionally, whether the by-products have an ecotoxicological effect on the environment and if there are any measured that can be taken to reduce the production of by-products. Method used to conduct this study was a systematic search over five databases and one search engine.
This study shows that by-products of EE2 are generated during ozonation. However, the results shows that there is a huge gap in knowledge, in regards to the amount of by-products created and in what concentration also their ecotoxcity and possible risk to the environment are mostly unknown. Some by-products have estrogenic activity and have shown to have detrimental effect on fetal rats testosterone secretion. This study shows therefore possible post ozonation treatment steps that could be implemented to reduce the potential toxicity of by-products reaching the environment. The knowledges gap needs to be corrected with future studies, as ozonation is one of the most likely treatment techniques for pharmaceuticals to be implemented in the future.},
  author       = {Svensson, Erica},
  keyword      = {Ethinylestradiol,EE2,By-products,Ozonation products,Transformation products,Ozonation},
  language     = {eng},
  note         = {Student Paper},
  title        = {A review on ozonation and17a-ethinylestradiol - formation and effects in the environment of the by-products},
  year         = {2017},
}