Skip to main content

LUP Student Papers

LUND UNIVERSITY LIBRARIES

Syntheses and Evaluation of Peptoids as Bioinert Coatings for Nanoparticles

Weber, Christoffer LU (2018) KASM05 20181
Centre for Analysis and Synthesis
Abstract
Polymers of N-substituted glycine (NSG) or as they are also called, peptoids,
have shown potential in biomedical applications due to proteolytic resistance, among other interesting properties.
In this thesis project, two synthetic routes have been performed and evaluated to
achieve a better understanding of large-scale syntheses of peptoids as a bioinert coating for nanoparticles. The primary focus has been on a solution-phase synthesis where the monomer, N-(3,6,9-trioxadecyl)glycine, has been synthesized via an oxidation of a primary alcohol to aldehyde followed by reductive amination. A “submonomer” approach, where the peptoid is grown on a resin in an iterative process of nucleophilic displacements and acylations, has also been... (More)
Polymers of N-substituted glycine (NSG) or as they are also called, peptoids,
have shown potential in biomedical applications due to proteolytic resistance, among other interesting properties.
In this thesis project, two synthetic routes have been performed and evaluated to
achieve a better understanding of large-scale syntheses of peptoids as a bioinert coating for nanoparticles. The primary focus has been on a solution-phase synthesis where the monomer, N-(3,6,9-trioxadecyl)glycine, has been synthesized via an oxidation of a primary alcohol to aldehyde followed by reductive amination. A “submonomer” approach, where the peptoid is grown on a resin in an iterative process of nucleophilic displacements and acylations, has also been performed but with a 3-methoxypropyl side chain. (Less)
Popular Abstract (Swedish)
Begränsningar med polyetylenglykol (PEG) som ytbeläggningen av proteiner och nanopartiklar i biologiska tillämpningar, har ökat intresset för peptoider. Peptoider har framställts med både en fastfassyntes och en syntes i lösningsmedel. Vad är mest lämpligt för storskalig framställning?
Please use this url to cite or link to this publication:
author
Weber, Christoffer LU
supervisor
organization
course
KASM05 20181
year
type
H2 - Master's Degree (Two Years)
subject
keywords
Peptoid, Antifouling, Polymer coating, Organic chemistry, Organisk kemi
language
English
id
8949100
date added to LUP
2018-06-25 09:02:01
date last changed
2018-06-25 09:02:01
@misc{8949100,
  abstract     = {{Polymers of N-substituted glycine (NSG) or as they are also called, peptoids, 
have shown potential in biomedical applications due to proteolytic resistance, among other interesting properties.
In this thesis project, two synthetic routes have been performed and evaluated to 
achieve a better understanding of large-scale syntheses of peptoids as a bioinert coating for nanoparticles. The primary focus has been on a solution-phase synthesis where the monomer, N-(3,6,9-trioxadecyl)glycine, has been synthesized via an oxidation of a primary alcohol to aldehyde followed by reductive amination. A “submonomer” approach, where the peptoid is grown on a resin in an iterative process of nucleophilic displacements and acylations, has also been performed but with a 3-methoxypropyl side chain.}},
  author       = {{Weber, Christoffer}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Syntheses and Evaluation of Peptoids as Bioinert Coatings for Nanoparticles}},
  year         = {{2018}},
}