Syntheses and Evaluation of Peptoids as Bioinert Coatings for Nanoparticles
(2018) KASM05 20181Centre for Analysis and Synthesis
- Abstract
- Polymers of N-substituted glycine (NSG) or as they are also called, peptoids,
have shown potential in biomedical applications due to proteolytic resistance, among other interesting properties.
In this thesis project, two synthetic routes have been performed and evaluated to
achieve a better understanding of large-scale syntheses of peptoids as a bioinert coating for nanoparticles. The primary focus has been on a solution-phase synthesis where the monomer, N-(3,6,9-trioxadecyl)glycine, has been synthesized via an oxidation of a primary alcohol to aldehyde followed by reductive amination. A “submonomer” approach, where the peptoid is grown on a resin in an iterative process of nucleophilic displacements and acylations, has also been... (More) - Polymers of N-substituted glycine (NSG) or as they are also called, peptoids,
have shown potential in biomedical applications due to proteolytic resistance, among other interesting properties.
In this thesis project, two synthetic routes have been performed and evaluated to
achieve a better understanding of large-scale syntheses of peptoids as a bioinert coating for nanoparticles. The primary focus has been on a solution-phase synthesis where the monomer, N-(3,6,9-trioxadecyl)glycine, has been synthesized via an oxidation of a primary alcohol to aldehyde followed by reductive amination. A “submonomer” approach, where the peptoid is grown on a resin in an iterative process of nucleophilic displacements and acylations, has also been performed but with a 3-methoxypropyl side chain. (Less) - Popular Abstract (Swedish)
- Begränsningar med polyetylenglykol (PEG) som ytbeläggningen av proteiner och nanopartiklar i biologiska tillämpningar, har ökat intresset för peptoider. Peptoider har framställts med både en fastfassyntes och en syntes i lösningsmedel. Vad är mest lämpligt för storskalig framställning?
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/8949100
- author
- Weber, Christoffer LU
- supervisor
-
- Peter Somfai LU
- organization
- course
- KASM05 20181
- year
- 2018
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Peptoid, Antifouling, Polymer coating, Organic chemistry, Organisk kemi
- language
- English
- id
- 8949100
- date added to LUP
- 2018-06-25 09:02:01
- date last changed
- 2018-06-25 09:02:01
@misc{8949100, abstract = {{Polymers of N-substituted glycine (NSG) or as they are also called, peptoids, have shown potential in biomedical applications due to proteolytic resistance, among other interesting properties. In this thesis project, two synthetic routes have been performed and evaluated to achieve a better understanding of large-scale syntheses of peptoids as a bioinert coating for nanoparticles. The primary focus has been on a solution-phase synthesis where the monomer, N-(3,6,9-trioxadecyl)glycine, has been synthesized via an oxidation of a primary alcohol to aldehyde followed by reductive amination. A “submonomer” approach, where the peptoid is grown on a resin in an iterative process of nucleophilic displacements and acylations, has also been performed but with a 3-methoxypropyl side chain.}}, author = {{Weber, Christoffer}}, language = {{eng}}, note = {{Student Paper}}, title = {{Syntheses and Evaluation of Peptoids as Bioinert Coatings for Nanoparticles}}, year = {{2018}}, }