Design of a lamellar phantom for multi-dimensional diffusion Magnetic Resonance Imaging (MRI)
(2019) KEMN30 20181Department of Chemistry
- Abstract
- Diffusion magnetic resonance imaging (dMRI) is a non-invasive method that provides micrometer or millimeter-scale tissue structural information. In order to further advance this technique to obtain more detailed microstructural information of biological tissues, developing new diffusion MRI method becomes a necessity.
For the past few years, the multidimensional diffusion MRI technique has been developed to advance clinical research by providing non-invasive techniques that enable exploration of pathological cellular changes, e.g. multiple sclerosis, cancer, Alzheimer’s disease and traumatic brain injury.
Phantom, as a specially designed object which mimics brain physiological conditions, is normally composed of water, polymer,... (More) - Diffusion magnetic resonance imaging (dMRI) is a non-invasive method that provides micrometer or millimeter-scale tissue structural information. In order to further advance this technique to obtain more detailed microstructural information of biological tissues, developing new diffusion MRI method becomes a necessity.
For the past few years, the multidimensional diffusion MRI technique has been developed to advance clinical research by providing non-invasive techniques that enable exploration of pathological cellular changes, e.g. multiple sclerosis, cancer, Alzheimer’s disease and traumatic brain injury.
Phantom, as a specially designed object which mimics brain physiological conditions, is normally composed of water, polymer, surfactant and hydrocarbons with tunable relaxation and diffusion property. The main purpose of this project is to design a lamellar liquid crystal phantom as a mean to validate multidimensional dMRI. The specific aim is to design a lamellar liquid crystal with transvers relaxation time (T2) as long as possible. The chemicals that we used are sodium octanoate (as surfactant) and 1-Deconal (as oil). As solution, we used a mixture of 90% Millipore-Q water and 10% heavy water. My work is basically described as follows. First, we mixed liquid crystals with different chemical compositions and then observed the samples by utilizing the polarized light microscopy. Second, we tested the samples by performing some NMR experiments. Specifically l measured deuterium NMR spectra and its transverse relaxation time T2, and then recorded NMR diffusion imaging for these samples. (Less) - Popular Abstract
- We know that biological tissues contain hundreds of thousands of microscopic domains of water. For different microstructure, the corresponding water mobility is different. By probing the effects of structure on water diffusion, the structure information of biological tissue can been obtained. This method is called diffusion magnetic resonance imaging (dMRI). dMRI is a non-invasive method that can give tissue structural information on micrometer-scale.
For the conventional dMRI, the spatial resolution of the images is limited that mean we obtain microscopic structures information has too lower revolution. In order to obtain more details information of biological tissues, new dMRI methods were developing in recent years. Our (Topgaard’s)... (More) - We know that biological tissues contain hundreds of thousands of microscopic domains of water. For different microstructure, the corresponding water mobility is different. By probing the effects of structure on water diffusion, the structure information of biological tissue can been obtained. This method is called diffusion magnetic resonance imaging (dMRI). dMRI is a non-invasive method that can give tissue structural information on micrometer-scale.
For the conventional dMRI, the spatial resolution of the images is limited that mean we obtain microscopic structures information has too lower revolution. In order to obtain more details information of biological tissues, new dMRI methods were developing in recent years. Our (Topgaard’s) group has a long history of developing new dMRI methods and utilizing them to study tissue microstructure of living human brain tissues. These methods are supposed to provide structural information at an unprecedented precise level.
In order to validate measurements of new diffusion MRI methods, developing phantoms are very necessary. Phantoms are special materials that mimic pathological conditions of biological tissues. Phantoms are utilized to optimize and validate measurements of new diffusion MRI methods. My thesis project is to design a lamellar liquid crystal phantom as a first step to validate new dMRI methods. Prior to my study, a phantom with diffusion properties corresponding to brain white matter was developed in our group. My work will follow the same line, but aiming to make a different phantom that mimic the microstructure of brain tumor tissue or epidermoid cyst. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/8965431
- author
- Jiang, Hong LU
- supervisor
- organization
- course
- KEMN30 20181
- year
- 2019
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Diffusion MRI, phantom, NMR, tensor, anisotropic, nanochemistry, nanokemi
- language
- English
- id
- 8965431
- date added to LUP
- 2019-02-25 09:04:21
- date last changed
- 2019-02-25 09:04:21
@misc{8965431,
abstract = {{Diffusion magnetic resonance imaging (dMRI) is a non-invasive method that provides micrometer or millimeter-scale tissue structural information. In order to further advance this technique to obtain more detailed microstructural information of biological tissues, developing new diffusion MRI method becomes a necessity.
For the past few years, the multidimensional diffusion MRI technique has been developed to advance clinical research by providing non-invasive techniques that enable exploration of pathological cellular changes, e.g. multiple sclerosis, cancer, Alzheimer’s disease and traumatic brain injury.
Phantom, as a specially designed object which mimics brain physiological conditions, is normally composed of water, polymer, surfactant and hydrocarbons with tunable relaxation and diffusion property. The main purpose of this project is to design a lamellar liquid crystal phantom as a mean to validate multidimensional dMRI. The specific aim is to design a lamellar liquid crystal with transvers relaxation time (T2) as long as possible. The chemicals that we used are sodium octanoate (as surfactant) and 1-Deconal (as oil). As solution, we used a mixture of 90% Millipore-Q water and 10% heavy water. My work is basically described as follows. First, we mixed liquid crystals with different chemical compositions and then observed the samples by utilizing the polarized light microscopy. Second, we tested the samples by performing some NMR experiments. Specifically l measured deuterium NMR spectra and its transverse relaxation time T2, and then recorded NMR diffusion imaging for these samples.}},
author = {{Jiang, Hong}},
language = {{eng}},
note = {{Student Paper}},
title = {{Design of a lamellar phantom for multi-dimensional diffusion Magnetic Resonance Imaging (MRI)}},
year = {{2019}},
}