Synthetic Approach towards N-acetylneuraminic Acid 5-C Amine Derivatives as Potential Drug Targets
(2021) KEMR30 20211Department of Chemistry
- Abstract
- Sialic acids are nine-carbon carbohydrates that are present and essential in nearly all mammalian cells. Sialic acids have many functions such as molecular recognition, cell adhesion, and markers for pathogens. Some pathogens can take advantage of mammalian sialic acids and disguise themselves as host cells in a phenomenon that is called pathogenic mimicry. By doing this, the bacteria and virus infect a host unnoticed as no immune response will recognize the threat. It is well known that P. Mirabilis and S. Aureus uses mimicry by harvesting host sialic acid as they cannot synthesize the sialic acid themselves. Furthermore, it has been shown that SARS-CoV-2 uses sialic acid as a co-factor when binding to the ACE2 receptor of humans. By... (More)
- Sialic acids are nine-carbon carbohydrates that are present and essential in nearly all mammalian cells. Sialic acids have many functions such as molecular recognition, cell adhesion, and markers for pathogens. Some pathogens can take advantage of mammalian sialic acids and disguise themselves as host cells in a phenomenon that is called pathogenic mimicry. By doing this, the bacteria and virus infect a host unnoticed as no immune response will recognize the threat. It is well known that P. Mirabilis and S. Aureus uses mimicry by harvesting host sialic acid as they cannot synthesize the sialic acid themselves. Furthermore, it has been shown that SARS-CoV-2 uses sialic acid as a co-factor when binding to the ACE2 receptor of humans. By exploiting the structure of sialic acid, we will synthesize an antagonist to these bacteria and viruses, thus functioning as an antibiotic or antiviral agent. This project will focus on the synthesis of C5 amine analogs of Neu5Ac to develop a library and increase the understanding and knowledge of how SARS-CoV-2 infects humans as well as finding an antibiotic inhibitor towards pathogenic bacteria. (Less)
- Popular Abstract (Swedish)
- Sialinsyra är en kolhydrat som finns i och på nästan alla däggdjursceller och fyller många funktioner. En viktig funktion är att agera som kommunikatör mellan celler. Många virus och bakterier använder sig av sialinsyra för att hitta rätt cell att infektera medan andra använder sialinsyra som en mantel för att gömma sig för immunförsvaret. Detta kan användas som ett verktyg för att utveckla medicin mot dessa infektiösa bakterier och virus då vi vet att de kommer attraheras av sialinsyror. Genom att göra små förändringar av sialinsyran så kan man stoppa bakteriens funktion att kunna ta upp sialinsyra och där med kan den inte förklä sig. Vårt mål med detta projekt är att hitta en modifierad sialinsyra som kan stoppa dessa funktioner från att... (More)
- Sialinsyra är en kolhydrat som finns i och på nästan alla däggdjursceller och fyller många funktioner. En viktig funktion är att agera som kommunikatör mellan celler. Många virus och bakterier använder sig av sialinsyra för att hitta rätt cell att infektera medan andra använder sialinsyra som en mantel för att gömma sig för immunförsvaret. Detta kan användas som ett verktyg för att utveckla medicin mot dessa infektiösa bakterier och virus då vi vet att de kommer attraheras av sialinsyror. Genom att göra små förändringar av sialinsyran så kan man stoppa bakteriens funktion att kunna ta upp sialinsyra och där med kan den inte förklä sig. Vårt mål med detta projekt är att hitta en modifierad sialinsyra som kan stoppa dessa funktioner från att fungera. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/9058162
- author
- Björklund, Joachim LU
- supervisor
- organization
- course
- KEMR30 20211
- year
- 2021
- type
- H2 - Master's Degree (Two Years)
- subject
- keywords
- Carbohydrate, Sialic acid, SARS-CoV-2, ACE2, SiaT transporter, 5C amide, C5 amide, Neu5Ac, Organic chemistry
- language
- English
- id
- 9058162
- date added to LUP
- 2021-07-01 15:49:50
- date last changed
- 2021-07-01 15:49:50
@misc{9058162,
abstract = {{Sialic acids are nine-carbon carbohydrates that are present and essential in nearly all mammalian cells. Sialic acids have many functions such as molecular recognition, cell adhesion, and markers for pathogens. Some pathogens can take advantage of mammalian sialic acids and disguise themselves as host cells in a phenomenon that is called pathogenic mimicry. By doing this, the bacteria and virus infect a host unnoticed as no immune response will recognize the threat. It is well known that P. Mirabilis and S. Aureus uses mimicry by harvesting host sialic acid as they cannot synthesize the sialic acid themselves. Furthermore, it has been shown that SARS-CoV-2 uses sialic acid as a co-factor when binding to the ACE2 receptor of humans. By exploiting the structure of sialic acid, we will synthesize an antagonist to these bacteria and viruses, thus functioning as an antibiotic or antiviral agent. This project will focus on the synthesis of C5 amine analogs of Neu5Ac to develop a library and increase the understanding and knowledge of how SARS-CoV-2 infects humans as well as finding an antibiotic inhibitor towards pathogenic bacteria.}},
author = {{Björklund, Joachim}},
language = {{eng}},
note = {{Student Paper}},
title = {{Synthetic Approach towards N-acetylneuraminic Acid 5-C Amine Derivatives as Potential Drug Targets}},
year = {{2021}},
}