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The assessment of the acute and second meal postprandial impact of plant polar lipid on glucose concentrations and satiety in healthy young adults

Ketelaars, Susie LU and van den Elzen, Wilmie LU (2024) KNLM01 20231
Food Technology and Nutrition (M.Sc.)
Abstract
Lifestyle modifications could be crucial in preventing and managing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD), including diet and postprandial glycaemic control. Previous studies on the effects of polar lipids (PLs) on postprandial metabolic responses at Lund University have shown conflicting results. To reconcile these findings and contribute to the existing literature, this study investigated the acute and second meal postprandial responses of blood glucose and subjective appetite parameters in healthy young adults consuming different concentrations of another plant PL preparation. A single-blind, randomised crossover study compared two doses of PL with reference samples. Twenty subjects consumed four solid test... (More)
Lifestyle modifications could be crucial in preventing and managing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD), including diet and postprandial glycaemic control. Previous studies on the effects of polar lipids (PLs) on postprandial metabolic responses at Lund University have shown conflicting results. To reconcile these findings and contribute to the existing literature, this study investigated the acute and second meal postprandial responses of blood glucose and subjective appetite parameters in healthy young adults consuming different concentrations of another plant PL preparation. A single-blind, randomised crossover study compared two doses of PL with reference samples. Twenty subjects consumed four solid test meals on different occasions, consisting of a standardised portion of white wheat flour bread supplemented with: i. 8 g PL (PLL), ii. 17 g PL (PLH), iii. 17 g commercial reference oil (RSO), iv. no added lipids (NL). Total fat content was equivalent in all meals. The test meals were given as breakfast, followed by a standardised lunch.

The results showed a significant reduction in postprandial blood glucose concentrations after breakfast with lipid-prepared test meals. PLH decreases blood glucose concentrations by 42% compared to NL, while RSO and PLL reduce blood glucose by 20% and 26%, respectively. Notably, a dose-response effect was observed, with PLH having a more significant effect on postprandial blood glucose concentrations than PLL, RSO and NL. Significant improvements in appetite were observed before the start of the second meal. These results were consistent with Hossain et al.'s (2021) randomised crossover study, strengthening evidence of the beneficial effects of plant PLs on postprandial glucose response and appetite regulation. Nevertheless, future investigation should focus on determining the minimal dose-response effect of PL and understanding the mechanisms underlying the effect of PL on blood glucose concentrations and appetite regulation. (Less)
Popular Abstract
‘Effects of a plant polar lipid on glucose concentrations and Satiety in healthy subjects’
Outcomes in a clinical study indicate that supplementing a breakfast meal with plant polar lipid X can reduce glucose responses both directly after the meal and after a second meal consumed 3.5 h thereafter.
These results show a promising preventative strategy for lifestyle-related diseases such as type 2 diabetes and obesity. The prevalence of these diseases is rising rapidly, resulting in global healthcare problems. In 2019, 9.3% of the world's population suffered from diabetes, and it is expected to rise to 10.9% by 2045; wow! Also, such diseases have intense consequences, e.g. cardiovascular diseases and early death. It is known that following... (More)
‘Effects of a plant polar lipid on glucose concentrations and Satiety in healthy subjects’
Outcomes in a clinical study indicate that supplementing a breakfast meal with plant polar lipid X can reduce glucose responses both directly after the meal and after a second meal consumed 3.5 h thereafter.
These results show a promising preventative strategy for lifestyle-related diseases such as type 2 diabetes and obesity. The prevalence of these diseases is rising rapidly, resulting in global healthcare problems. In 2019, 9.3% of the world's population suffered from diabetes, and it is expected to rise to 10.9% by 2045; wow! Also, such diseases have intense consequences, e.g. cardiovascular diseases and early death. It is known that following a healthy lifestyle and controlling postprandial blood glucose levels are essential to counteract or prevent these diseases; however, specific preventative strategies are still urgently needed. Studying the effect of plant polar lipids is becoming more attractive due to their suggested metabolic effects.
In this diploma work, we investigated the effect of two different doses of a polar lipid of plant origin (PL X), on blood glucose levels and satiety sensations. The lipids were incorporated in a spread (blended with glucose, cacao and water) and served on white wheat bread. The results were compared with the effects of a commercial reference oil and controlled with a negative sample containing no lipids, all included 43 g of available carbohydrates. A randomised cross-over single-blind study was performed on 20 healthy subjects. Requirements were; aged 20 - 40 years, BMI 19-28 kg/m2, non-smoker and no metabolic disorder or food allergy. A typical experiment day started with a breakfast meal, including one of the test products, and blood glucose levels were measured for up to 3.5 hours. Then, a standardised lunch meal was given, composed of mashed potato and vegetarian meatballs. Blood glucose measurements continued up to 2.5 hours after lunch. Meanwhile, subjects filled in a (100 mm) scale with questions about their fullness, hunger and desire to eat.
In line with previous studies, the results indicated an improved postprandial acute and second-meal blood glucose response following a supplemented breakfast meal with PL X. Additionally, satiety sensations were improved by PL X right before lunch. These results imply that PL X helps control postprandial blood glucose responses, prolong satiety feelings and thereby might help control food intake and prevent obesity and type 2 diabetes. However, studying the effect of PL X on blood glucose levels and satiety is relatively new, so there is a need for further studies to reinforce the results of this study and to find the underlying mechanisms. (Less)
Please use this url to cite or link to this publication:
author
Ketelaars, Susie LU and van den Elzen, Wilmie LU
supervisor
organization
alternative title
The assessment of the acute and second meal postprandial impact of plant polar lipid on blood glucose concentrations and satiety in healthy young adults
course
KNLM01 20231
year
type
H2 - Master's Degree (Two Years)
subject
keywords
postprandial blood glucose, plant polar lipid, type 2 diabetes mellitus, appetite regulation, dose-response effect, applied nutrition and food chemistry
language
English
id
9124226
date added to LUP
2023-06-22 09:28:06
date last changed
2023-06-22 09:28:06
@misc{9124226,
  abstract     = {{Lifestyle modifications could be crucial in preventing and managing type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD), including diet and postprandial glycaemic control. Previous studies on the effects of polar lipids (PLs) on postprandial metabolic responses at Lund University have shown conflicting results. To reconcile these findings and contribute to the existing literature, this study investigated the acute and second meal postprandial responses of blood glucose and subjective appetite parameters in healthy young adults consuming different concentrations of another plant PL preparation. A single-blind, randomised crossover study compared two doses of PL with reference samples. Twenty subjects consumed four solid test meals on different occasions, consisting of a standardised portion of white wheat flour bread supplemented with: i. 8 g PL (PLL), ii. 17 g PL (PLH), iii. 17 g commercial reference oil (RSO), iv. no added lipids (NL). Total fat content was equivalent in all meals. The test meals were given as breakfast, followed by a standardised lunch. 
 
The results showed a significant reduction in postprandial blood glucose concentrations after breakfast with lipid-prepared test meals. PLH decreases blood glucose concentrations by 42% compared to NL, while RSO and PLL reduce blood glucose by 20% and 26%, respectively. Notably, a dose-response effect was observed, with PLH having a more significant effect on postprandial blood glucose concentrations than PLL, RSO and NL. Significant improvements in appetite were observed before the start of the second meal. These results were consistent with Hossain et al.'s (2021) randomised crossover study, strengthening evidence of the beneficial effects of plant PLs on postprandial glucose response and appetite regulation. Nevertheless, future investigation should focus on determining the minimal dose-response effect of PL and understanding the mechanisms underlying the effect of PL on blood glucose concentrations and appetite regulation.}},
  author       = {{Ketelaars, Susie and van den Elzen, Wilmie}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{The assessment of the acute and second meal postprandial impact of plant polar lipid on glucose concentrations and satiety in healthy young adults}},
  year         = {{2024}},
}