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Natural Deep Eutectic Solvents - An Investigation of the Relation Between Solvent Composition and Apigenin as an Extractable

Aliwi, Abbas LU (2025) KEMK10 20251
Department of Chemistry
Abstract
Introduction: A Natural Deep Eutectic Solvent (NaDES) is presumably a green and cost-effective eutectic solvent, capable of extracting many different types of analytes. The analyte, apigenin, is a potential nutraceutical compound with anti-diabetic properties.
Background: NaDES compositional variation and unknown properties challenges prediction of their extraction selectivity.
Aim(s): Correlate NaDES composition and properties to recovery and extraction yields, in relation to apigenin properties. Discuss optimization of physical parameters for extraction.
Methods: A literature search was made on Scifinder to find articles that experimented with recovery and extractions. Articles that reported data on recovery/extraction yields were... (More)
Introduction: A Natural Deep Eutectic Solvent (NaDES) is presumably a green and cost-effective eutectic solvent, capable of extracting many different types of analytes. The analyte, apigenin, is a potential nutraceutical compound with anti-diabetic properties.
Background: NaDES compositional variation and unknown properties challenges prediction of their extraction selectivity.
Aim(s): Correlate NaDES composition and properties to recovery and extraction yields, in relation to apigenin properties. Discuss optimization of physical parameters for extraction.
Methods: A literature search was made on Scifinder to find articles that experimented with recovery and extractions. Articles that reported data on recovery/extraction yields were collected. Search string: ((“nades” OR “natural deep eutectic solvents”) AND “apigenin”)
Results: 48 hits were found, and 10 articles were deemed relevant to the subject. Through descriptive analysis, yields were compared, and a few trends were found and proposed. In general, sugar derivates saw the highest yields while the aglycone variant saw lower yields due to NaDES hydrophilicity.
Conclusion and future perspective: More systematic experimental studies need to be conducted to allow for efficient modelling of NaDES composition and yield. Statistical models need to be done to find trends and to evaluate the significance of them. (Less)
Popular Abstract
Investigating The Natural Deep Eutectic Solvent’s Extractability of Apigenin
Natural Deep Eutectic Solvents (NaDES) are a group of environmentally friendly, inexpensive solvents that have become known for their ability to extract a multitude of chemical compounds from a variety of foods, plants and chemical media. They require minimal preparation and mild conditions, making them easy to use. The issue is that their selectivity is poorly understood. This report aims to investigate how NaDES composition is related to compound selectivity, as well as investigate how different physical parameters can influence extractions of apigenin, a compound with potential medical relevance.
This work was conducted by searching for scientific articles... (More)
Investigating The Natural Deep Eutectic Solvent’s Extractability of Apigenin
Natural Deep Eutectic Solvents (NaDES) are a group of environmentally friendly, inexpensive solvents that have become known for their ability to extract a multitude of chemical compounds from a variety of foods, plants and chemical media. They require minimal preparation and mild conditions, making them easy to use. The issue is that their selectivity is poorly understood. This report aims to investigate how NaDES composition is related to compound selectivity, as well as investigate how different physical parameters can influence extractions of apigenin, a compound with potential medical relevance.
This work was conducted by searching for scientific articles that experiment with NaDES and publish data on extractions and recoveries of apigenin (and the sugar-based forms), by using keywords related to NaDES and extractions. followed by data collection and a descriptive analysis of the trends in extractability.
It was found that several factors play at hand when extracting apigenin. Some that influence the chemical state of apigenin but also factors that influence apigenin’s chemical structure in the NaDES, as well as the molecular interactions between both. All of which affect extraction and recovery yields. What can also be done for future endeavours is to focus on doing systematic experiments on NaDES and use statistical tools to find correlations, while accounting for the abovementioned factors. (Less)
Please use this url to cite or link to this publication:
author
Aliwi, Abbas LU
supervisor
organization
course
KEMK10 20251
year
type
M2 - Bachelor Degree
subject
keywords
analytical chemistry, apigenin, extraction, hydrogen bonding, NaDES, recovery
language
English
id
9213034
date added to LUP
2025-09-24 13:43:50
date last changed
2025-09-24 13:43:50
@misc{9213034,
  abstract     = {{Introduction: A Natural Deep Eutectic Solvent (NaDES) is presumably a green and cost-effective eutectic solvent, capable of extracting many different types of analytes. The analyte, apigenin, is a potential nutraceutical compound with anti-diabetic properties.
Background: NaDES compositional variation and unknown properties challenges prediction of their extraction selectivity.
Aim(s): Correlate NaDES composition and properties to recovery and extraction yields, in relation to apigenin properties. Discuss optimization of physical parameters for extraction. 
Methods: A literature search was made on Scifinder to find articles that experimented with recovery and extractions. Articles that reported data on recovery/extraction yields were collected. Search string: ((“nades” OR “natural deep eutectic solvents”) AND “apigenin”)
Results: 48 hits were found, and 10 articles were deemed relevant to the subject. Through descriptive analysis, yields were compared, and a few trends were found and proposed. In general, sugar derivates saw the highest yields while the aglycone variant saw lower yields due to NaDES hydrophilicity.
Conclusion and future perspective: More systematic experimental studies need to be conducted to allow for efficient modelling of NaDES composition and yield. Statistical models need to be done to find trends and to evaluate the significance of them.}},
  author       = {{Aliwi, Abbas}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Natural Deep Eutectic Solvents - An Investigation of the Relation Between Solvent Composition and Apigenin as an Extractable}},
  year         = {{2025}},
}