Skip to main content

LUP Student Papers

LUND UNIVERSITY LIBRARIES

Towards a novel, efficient, and green route to Zanamivir

Panican, Rebeca LU (2026) KEML10 20252
Department of Chemistry
Abstract
In this study, a novel route to synthesising Zanamivir have been accomplished. In the past two decades, many scientists have struggled to find a green and step-economical route to synthesising Zanamivir. None have succeeded to insert guanidine; thus, relying on amination and reduction with explosive azido reagents, causing the synthesis to be far too long and hazardous. Our aim was to shorten the route by finding optimal conditions to insert guanidine in an early stage and exceeding current route by using greener reagents. Henceforth, a screening test and a design of experiment was constructed and performed. Thus, we were able to substitute guanidine into two precursors. Moreover, we have established a pathway, consisting of only 5 steps,... (More)
In this study, a novel route to synthesising Zanamivir have been accomplished. In the past two decades, many scientists have struggled to find a green and step-economical route to synthesising Zanamivir. None have succeeded to insert guanidine; thus, relying on amination and reduction with explosive azido reagents, causing the synthesis to be far too long and hazardous. Our aim was to shorten the route by finding optimal conditions to insert guanidine in an early stage and exceeding current route by using greener reagents. Henceforth, a screening test and a design of experiment was constructed and performed. Thus, we were able to substitute guanidine into two precursors. Moreover, we have established a pathway, consisting of only 5 steps, to Zanamivir. Our novel and short synthesis exceeds the current routes when considering two main aspects, namely, environmental and economical. Lastly, we have also provided an approach which could be used as a generic procedure to solve other synthetic complexities. (Less)
Popular Abstract (Swedish)
I dagens samhälle kan människor med sårbarhetsfaktorer, såsom ålderdom eller respiratoriska sjukdomar, riskera att dö när de utsätts för virusinfektioner. Det figurerar ständigt olika influensavarianter bland oss som vissa kan tillfriskna från utan några mediciner, men de individer som har en uttalade sårbarhet behöver antivirala läkemedel för att bekämpa viruset. Ett av dessa läkemedel är Zanamivir, vilket utvecklades för mer än två årtionden sedan. Läkemedlet finns på marknaden, men den kommersiella tillverkningsvägen brister i effektivitet och miljövänlighet. Detta har lett till stora produktionskostnader. I detta arbete presenteras en ny väg som är kortare och mer miljövänlig än nuvarande synteser, vilket därmed gör den mer... (More)
I dagens samhälle kan människor med sårbarhetsfaktorer, såsom ålderdom eller respiratoriska sjukdomar, riskera att dö när de utsätts för virusinfektioner. Det figurerar ständigt olika influensavarianter bland oss som vissa kan tillfriskna från utan några mediciner, men de individer som har en uttalade sårbarhet behöver antivirala läkemedel för att bekämpa viruset. Ett av dessa läkemedel är Zanamivir, vilket utvecklades för mer än två årtionden sedan. Läkemedlet finns på marknaden, men den kommersiella tillverkningsvägen brister i effektivitet och miljövänlighet. Detta har lett till stora produktionskostnader. I detta arbete presenteras en ny väg som är kortare och mer miljövänlig än nuvarande synteser, vilket därmed gör den mer kostnadseffektiv och attraktiv på marknaden. (Less)
Please use this url to cite or link to this publication:
author
Panican, Rebeca LU
supervisor
organization
course
KEML10 20252
year
type
M2 - Bachelor Degree
subject
keywords
Antiviral drug, Efficient, Novel synthesis, Step-economical, Organic chemistry
language
English
id
9220958
date added to LUP
2026-01-29 11:02:41
date last changed
2026-01-29 11:02:41
@misc{9220958,
  abstract     = {{In this study, a novel route to synthesising Zanamivir have been accomplished. In the past two decades, many scientists have struggled to find a green and step-economical route to synthesising Zanamivir. None have succeeded to insert guanidine; thus, relying on amination and reduction with explosive azido reagents, causing the synthesis to be far too long and hazardous. Our aim was to shorten the route by finding optimal conditions to insert guanidine in an early stage and exceeding current route by using greener reagents. Henceforth, a screening test and a design of experiment was constructed and performed. Thus, we were able to substitute guanidine into two precursors. Moreover, we have established a pathway, consisting of only 5 steps, to Zanamivir. Our novel and short synthesis exceeds the current routes when considering two main aspects, namely, environmental and economical. Lastly, we have also provided an approach which could be used as a generic procedure to solve other synthetic complexities.}},
  author       = {{Panican, Rebeca}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Towards a novel, efficient, and green route to Zanamivir}},
  year         = {{2026}},
}