Risk-tailored starting age of breast cancer screening based on women's reproductive profile : A nationwide cohort study
(2020) In European Journal of Cancer 124. p.207-213- Abstract
Background: Although reproductive history is recognised to affect the risk of breast cancer, current breast cancer screening guidelines do not consider risk differences by this important factor. As there is a need for an earlier screening in women at increased risk of breast cancer, we provided evidence-based risk-adapted starting age of screening based on different reproductive profiles.
Material and methods: We conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931. Records of study participants in Swedish Cancer Registry, Multi-generation Register, Cause of Death Register, and national censuses (follow-up, 1958–2015) have been linked. We used 10-year cumulative risk of breast cancer curves to... (More)
Background: Although reproductive history is recognised to affect the risk of breast cancer, current breast cancer screening guidelines do not consider risk differences by this important factor. As there is a need for an earlier screening in women at increased risk of breast cancer, we provided evidence-based risk-adapted starting age of screening based on different reproductive profiles.
Material and methods: We conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931. Records of study participants in Swedish Cancer Registry, Multi-generation Register, Cause of Death Register, and national censuses (follow-up, 1958–2015) have been linked. We used 10-year cumulative risk of breast cancer curves to determine the age at which women with different reproductive factors attained the risk level at which breast screening is usually recommended.
Results: The 10-year cumulative risk of breast cancer at age 40, 45 and 50 years in the general population, at which current screening guidelines recommend screening was calculated. We found that women with various reproductive factors (defined by parity and age at first birth) obtained this level of risk at different ages. The difference was between nine years later and three years earlier.
Conclusions: This study provides the age at which women with particular reproductive profile could start risk-adapted breast cancer screening. This supplies novel information for clinicians and women about when to start breast cancer screening and is an important step towards a personalised screening.
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- author
- Mukama, Trasias LU ; Fallah, Mahdi LU ; Tian, Yu ; Sundquist, Kristina LU ; Sundquist, Jan LU ; Brenner, Hermann LU and Kharazmi, Elham LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Age at first birth, Breast cancer, Parity, Reproductive factors, Risk-adapted screening, Screening, Sporadic breast cancer
- in
- European Journal of Cancer
- volume
- 124
- pages
- 207 - 213
- publisher
- Elsevier
- external identifiers
-
- pmid:31761537
- scopus:85075816160
- ISSN
- 0959-8049
- DOI
- 10.1016/j.ejca.2019.10.011
- language
- English
- LU publication?
- yes
- id
- 05415921-308c-4b94-aee3-0028e24e22e3
- date added to LUP
- 2019-12-16 13:17:52
- date last changed
- 2024-09-04 14:05:39
@article{05415921-308c-4b94-aee3-0028e24e22e3,
abstract = {{<p>Background: Although reproductive history is recognised to affect the risk of breast cancer, current breast cancer screening guidelines do not consider risk differences by this important factor. As there is a need for an earlier screening in women at increased risk of breast cancer, we provided evidence-based risk-adapted starting age of screening based on different reproductive profiles. </p><p>Material and methods: We conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931. Records of study participants in Swedish Cancer Registry, Multi-generation Register, Cause of Death Register, and national censuses (follow-up, 1958–2015) have been linked. We used 10-year cumulative risk of breast cancer curves to determine the age at which women with different reproductive factors attained the risk level at which breast screening is usually recommended. </p><p>Results: The 10-year cumulative risk of breast cancer at age 40, 45 and 50 years in the general population, at which current screening guidelines recommend screening was calculated. We found that women with various reproductive factors (defined by parity and age at first birth) obtained this level of risk at different ages. The difference was between nine years later and three years earlier. </p><p>Conclusions: This study provides the age at which women with particular reproductive profile could start risk-adapted breast cancer screening. This supplies novel information for clinicians and women about when to start breast cancer screening and is an important step towards a personalised screening.</p>}},
author = {{Mukama, Trasias and Fallah, Mahdi and Tian, Yu and Sundquist, Kristina and Sundquist, Jan and Brenner, Hermann and Kharazmi, Elham}},
issn = {{0959-8049}},
keywords = {{Age at first birth; Breast cancer; Parity; Reproductive factors; Risk-adapted screening; Screening; Sporadic breast cancer}},
language = {{eng}},
pages = {{207--213}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{Risk-tailored starting age of breast cancer screening based on women's reproductive profile : A nationwide cohort study}},
url = {{http://dx.doi.org/10.1016/j.ejca.2019.10.011}},
doi = {{10.1016/j.ejca.2019.10.011}},
volume = {{124}},
year = {{2020}},
}