Combined density and size-based sorting in deterministic lateral displacement devices
(2013) 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 2. p.1224-1226- Abstract
We present a deterministic-lateral-displacement (DLD) device that extends the capabilities of this traditionally sizebased particle separation technique to also be sensitive to density. By the use of T-shaped posts instead of the normally cylindrical posts the particle trajectory through the device will be a function of its vertical position which in turn is determined by the buoyancy of the particles. The potential lies in fast sorting of complex biological samples together with diagnosis and treatment-monitoring of diseases affecting cell-density, eg. cancer, sickle-cell anemia and malaria. We demonstrate proof-of-principle of combined size-and-density-based sorting, specifically particles of identical size but different density.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/085889a4-5c38-4110-9117-00f2df27749e
- author
- Holm, Stefan H. LU ; Beech, Jason P. LU and Tegenfeldt, Jonas O. LU
- organization
- publishing date
- 2013-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Density, Deterministic lateral displacement, Fractionation
- host publication
- 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
- volume
- 2
- pages
- 3 pages
- publisher
- Chemical and Biological Microsystems Society
- conference name
- 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
- conference location
- Freiburg, Germany
- conference dates
- 2013-10-27 - 2013-10-31
- external identifiers
-
- scopus:84907300362
- ISBN
- 9781632666246
- language
- English
- LU publication?
- yes
- id
- 085889a4-5c38-4110-9117-00f2df27749e
- date added to LUP
- 2018-10-20 08:42:32
- date last changed
- 2023-09-08 09:25:05
@inproceedings{085889a4-5c38-4110-9117-00f2df27749e, abstract = {{<p>We present a deterministic-lateral-displacement (DLD) device that extends the capabilities of this traditionally sizebased particle separation technique to also be sensitive to density. By the use of T-shaped posts instead of the normally cylindrical posts the particle trajectory through the device will be a function of its vertical position which in turn is determined by the buoyancy of the particles. The potential lies in fast sorting of complex biological samples together with diagnosis and treatment-monitoring of diseases affecting cell-density, eg. cancer, sickle-cell anemia and malaria. We demonstrate proof-of-principle of combined size-and-density-based sorting, specifically particles of identical size but different density.</p>}}, author = {{Holm, Stefan H. and Beech, Jason P. and Tegenfeldt, Jonas O.}}, booktitle = {{17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013}}, isbn = {{9781632666246}}, keywords = {{Density; Deterministic lateral displacement; Fractionation}}, language = {{eng}}, month = {{01}}, pages = {{1224--1226}}, publisher = {{Chemical and Biological Microsystems Society}}, title = {{Combined density and size-based sorting in deterministic lateral displacement devices}}, volume = {{2}}, year = {{2013}}, }