Degradation of human secretory immunoglobulin A by Blastocystis
(2005) In Parasitology Research 97(5). p.9-386- Abstract
Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B. hominis B isolate and aspartic proteinase activity in B. ratii WR1 isolate. These findings suggest that Blastocystis proteases may play a role in parasite survival in vivo.
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- author
- Puthia, Manoj K LU ; Vaithilingam, Aparna ; Lu, Jia and Tan, Kevin S W
- publishing date
- 2005-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Aspartic Acid Endopeptidases/metabolism, Blastocystis/enzymology, Blastocystis hominis/enzymology, Culture Media, Conditioned/metabolism, Cysteine Endopeptidases/metabolism, Humans, Immunoglobulin A, Secretory/metabolism, Rats
- in
- Parasitology Research
- volume
- 97
- issue
- 5
- pages
- 4 pages
- publisher
- Springer
- external identifiers
-
- pmid:16151742
- scopus:27644585194
- ISSN
- 0932-0113
- DOI
- 10.1007/s00436-005-1461-0
- language
- English
- LU publication?
- no
- id
- 0a16dd0c-8380-44cd-abae-f8029b54e18e
- date added to LUP
- 2018-08-27 13:49:37
- date last changed
- 2024-08-20 22:11:48
@article{0a16dd0c-8380-44cd-abae-f8029b54e18e, abstract = {{<p>Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B. hominis B isolate and aspartic proteinase activity in B. ratii WR1 isolate. These findings suggest that Blastocystis proteases may play a role in parasite survival in vivo.</p>}}, author = {{Puthia, Manoj K and Vaithilingam, Aparna and Lu, Jia and Tan, Kevin S W}}, issn = {{0932-0113}}, keywords = {{Animals; Aspartic Acid Endopeptidases/metabolism; Blastocystis/enzymology; Blastocystis hominis/enzymology; Culture Media, Conditioned/metabolism; Cysteine Endopeptidases/metabolism; Humans; Immunoglobulin A, Secretory/metabolism; Rats}}, language = {{eng}}, number = {{5}}, pages = {{9--386}}, publisher = {{Springer}}, series = {{Parasitology Research}}, title = {{Degradation of human secretory immunoglobulin A by Blastocystis}}, url = {{http://dx.doi.org/10.1007/s00436-005-1461-0}}, doi = {{10.1007/s00436-005-1461-0}}, volume = {{97}}, year = {{2005}}, }