Age-Related Changes in Immunological and Physiological Responses Following Pulmonary Challenge
(2017) In International Journal of Molecular Sciences 18(6).- Abstract
- This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, but it is during infectious insult of the lungs, as in the case of pneumonia, that the age-related differences in responsiveness and endurance become obvious and lead to a worse outcome than in the younger population. This review points to the neutrophil, and the endothelium as important players in understanding age-associated changes in... (More)
- This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, but it is during infectious insult of the lungs, as in the case of pneumonia, that the age-related differences in responsiveness and endurance become obvious and lead to a worse outcome than in the younger population. This review points to the neutrophil, and the endothelium as important players in understanding age-associated changes in responsiveness to infectious challenge of the lung. It also addresses how the immunological set-point influences injury-repair phases, remote organ damage and how intake of drugs may alter the state of responsiveness in the users. Further, it points out the importance of considering age as a factor in inclusion criteria in clinical trials, in vitro/ex vivo experimental designs and overall interpretation of results. (Less)
- Abstract (Swedish)
- Abstract: This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, but it is during infectious insult of the lungs, as in
the case of pneumonia, that the age-related differences in responsiveness and endurance become obvious and lead to a worse outcome than in the younger population. This review points to the neutrophil, and the endothelium as important players in understanding age-associated changes... (More) - Abstract: This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, but it is during infectious insult of the lungs, as in
the case of pneumonia, that the age-related differences in responsiveness and endurance become obvious and lead to a worse outcome than in the younger population. This review points to the neutrophil, and the endothelium as important players in understanding age-associated changes in responsiveness to infectious challenge of the lung. It also addresses how the immunological set-point influences injury-repair phases, remote organ damage and how intake of drugs may alter the state of responsiveness in the users. Further, it points out the importance of considering age as a factor in inclusion criteria in clinical trials, in vitro/ex vivo experimental designs and overall interpretation
of results. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/0f1e16e0-d6a5-410f-b92e-4fee15f827d1
- author
- Miller, Edmund J and Linge, Helena LU
- organization
- publishing date
- 2017-06-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Molecular Sciences
- volume
- 18
- issue
- 6
- article number
- 1294
- publisher
- MDPI AG
- external identifiers
-
- pmid:28629122
- scopus:85020936737
- wos:000404581500191
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms18061294
- language
- English
- LU publication?
- yes
- id
- 0f1e16e0-d6a5-410f-b92e-4fee15f827d1
- date added to LUP
- 2017-06-22 10:17:18
- date last changed
- 2022-04-17 02:37:07
@article{0f1e16e0-d6a5-410f-b92e-4fee15f827d1,
abstract = {{This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, but it is during infectious insult of the lungs, as in the case of pneumonia, that the age-related differences in responsiveness and endurance become obvious and lead to a worse outcome than in the younger population. This review points to the neutrophil, and the endothelium as important players in understanding age-associated changes in responsiveness to infectious challenge of the lung. It also addresses how the immunological set-point influences injury-repair phases, remote organ damage and how intake of drugs may alter the state of responsiveness in the users. Further, it points out the importance of considering age as a factor in inclusion criteria in clinical trials, in vitro/ex vivo experimental designs and overall interpretation of results.}},
author = {{Miller, Edmund J and Linge, Helena}},
issn = {{1661-6596}},
language = {{eng}},
month = {{06}},
number = {{6}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Age-Related Changes in Immunological and Physiological Responses Following Pulmonary Challenge}},
url = {{http://dx.doi.org/10.3390/ijms18061294}},
doi = {{10.3390/ijms18061294}},
volume = {{18}},
year = {{2017}},
}