Comparison of three methods to find the vapor activity of a hydration step
(2001) In European Journal of Pharmaceutics and Biopharmaceutics 51(1). p.77-81- Abstract
- The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1034515
- author
- Wadsö, Lars LU and Markova, N
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Pharmaceutics and Biopharmaceutics
- volume
- 51
- issue
- 1
- pages
- 77 - 81
- publisher
- Elsevier
- external identifiers
-
- scopus:0035168377
- ISSN
- 0939-6411
- DOI
- 10.1016/S0939-6411(00)00134-X
- language
- English
- LU publication?
- yes
- id
- e93584dc-ecac-4e02-81f9-c741532e292b (old id 1034515)
- date added to LUP
- 2016-04-01 12:25:13
- date last changed
- 2022-01-27 03:27:31
@article{e93584dc-ecac-4e02-81f9-c741532e292b, abstract = {{The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.}}, author = {{Wadsö, Lars and Markova, N}}, issn = {{0939-6411}}, language = {{eng}}, number = {{1}}, pages = {{77--81}}, publisher = {{Elsevier}}, series = {{European Journal of Pharmaceutics and Biopharmaceutics}}, title = {{Comparison of three methods to find the vapor activity of a hydration step}}, url = {{http://dx.doi.org/10.1016/S0939-6411(00)00134-X}}, doi = {{10.1016/S0939-6411(00)00134-X}}, volume = {{51}}, year = {{2001}}, }