B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.
Andreasson, Ulrika LU
; Ek, Sara
LU
; Merz, Hartmut
; Rosenquist, Richard
; Andersen, Niels
; Jerkeman, Mats
LU
; Dictor, Michael
LU
and Borrebaeck, Carl A K
(2008)
In Cancer Letters
259(2).
p.138-145
- Abstract
- To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to... (More)
- To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1035621
- author
- Andreasson, Ulrika
LU
; Ek, Sara
LU
; Merz, Hartmut
; Rosenquist, Richard
; Andersen, Niels
; Jerkeman, Mats
LU
; Dictor, Michael
LU
and Borrebaeck, Carl A K
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Letters
- volume
- 259
- issue
- 2
- pages
- 138 - 145
- publisher
- Elsevier
- external identifiers
-
- pmid:18060687
- wos:000253023100002
- scopus:37049035312
- pmid:18060687
- ISSN
- 1872-7980
- DOI
- 10.1016/j.canlet.2007.10.031
- language
- English
- LU publication?
- yes
- id
- 76ff3643-38af-4699-92e1-05027d5d526a (old id 1035621)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18060687?dopt=Abstract
- date added to LUP
- 2016-04-04 09:07:25
- date last changed
- 2022-01-29 08:22:48
@article{76ff3643-38af-4699-92e1-05027d5d526a,
abstract = {{To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX(3)CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX(3)CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX(3)CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX(3)CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.}},
author = {{Andreasson, Ulrika and Ek, Sara and Merz, Hartmut and Rosenquist, Richard and Andersen, Niels and Jerkeman, Mats and Dictor, Michael and Borrebaeck, Carl A K}},
issn = {{1872-7980}},
language = {{eng}},
number = {{2}},
pages = {{138--145}},
publisher = {{Elsevier}},
series = {{Cancer Letters}},
title = {{B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule.}},
url = {{http://dx.doi.org/10.1016/j.canlet.2007.10.031}},
doi = {{10.1016/j.canlet.2007.10.031}},
volume = {{259}},
year = {{2008}},
}