Xylose as a carrier for boron containing compounds.
Jacobsson, Mårten LU ; Winander, Cecilia ; Mani, Katrin LU
and Ellervik, Ulf
LU
(2008)
In Bioorganic & Medicinal Chemistry Letters
18(7).
p.2451-2454
- Abstract
- A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other... (More)
- A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other tumor cell lines. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1052767
- author
- Jacobsson, Mårten
LU
; Winander, Cecilia
; Mani, Katrin
LU
and Ellervik, Ulf
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Bioorganic & Medicinal Chemistry Letters
- volume
- 18
- issue
- 7
- pages
- 2451 - 2454
- publisher
- Elsevier
- external identifiers
-
- pmid:18325767
- wos:000255246300042
- scopus:41249087878
- ISSN
- 0960-894X
- DOI
- 10.1016/j.bmcl.2008.02.048
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Department of Experimental Medical Science (013210000), Glycobiology (013212006)
- id
- ddb04f83-7700-4b29-9f02-86ef93c542aa (old id 1052767)
- date added to LUP
- 2016-04-01 14:07:18
- date last changed
- 2023-09-03 09:41:37
@article{ddb04f83-7700-4b29-9f02-86ef93c542aa,
abstract = {{A xylosylated carborane was synthesized by standard carbohydrate methodology and tested on normal HFL-1 cells as well as transformed T24 cells. The xylosylated carborane initiated glycosaminoglycan (GAG) synthesis in both cell lines and treatment with the carborane gave a pronounced translocation of proteoglycans to the nuclei of T24 cells. However, most of the boron-containing compounds were secreted to the medium. We conclude that xylosides carrying carboranes are not suitable for boron neutron capture therapy (BNCT) for T24 cells. However, the uptake of boron-containing xyloside, the GAG priming capacity, and the nuclear translocation of glypican-1 make this xyloside a candidate for further investigation for selectivity toward other tumor cell lines.}},
author = {{Jacobsson, Mårten and Winander, Cecilia and Mani, Katrin and Ellervik, Ulf}},
issn = {{0960-894X}},
language = {{eng}},
number = {{7}},
pages = {{2451--2454}},
publisher = {{Elsevier}},
series = {{Bioorganic & Medicinal Chemistry Letters}},
title = {{Xylose as a carrier for boron containing compounds.}},
url = {{http://dx.doi.org/10.1016/j.bmcl.2008.02.048}},
doi = {{10.1016/j.bmcl.2008.02.048}},
volume = {{18}},
year = {{2008}},
}