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Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantation.

Ghosh, Fredrik LU ; Hansson, Lars-Jörgen ; Bynke, Gunnel LU and Békássy, Albert LU (2002) In Acta Ophthalmologica Scandinavica 80(1). p.101-104
Abstract
Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae. His immune system at this time was almost completely depleted. Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment. RESULTS: No per- or postoperative complications were noted. Infiltrates, hemorrhages and macular edema present... (More)
Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae. His immune system at this time was almost completely depleted. Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment. RESULTS: No per- or postoperative complications were noted. Infiltrates, hemorrhages and macular edema present preoperatively dissolved over a period of six months. The final visual acuity was 1.0 in both eyes. The patients immune system and lung function slowly recovered during the same time period. CONCLUSIONS: The intravitreal ganciclovir implant provides safe and effective therapy against CMV retinitis, and should be considered in patients acquiring the infection after stem cell transplantation. (Less)
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type
Contribution to journal
publication status
published
subject
in
Acta Ophthalmologica Scandinavica
volume
80
issue
1
pages
101 - 104
publisher
Wiley
external identifiers
  • pmid:11906315
  • wos:000174388300021
  • scopus:0036250164
ISSN
1395-3907
DOI
10.1034/j.1600-0420.2002.800121.x
language
English
LU publication?
yes
id
4bb42d28-3e76-44d1-8138-9779994f72c0 (old id 105857)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11906315&dopt=Abstract
date added to LUP
2016-04-01 16:19:46
date last changed
2022-03-14 23:46:03
@article{4bb42d28-3e76-44d1-8138-9779994f72c0,
  abstract     = {{Purpose: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation. METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae. His immune system at this time was almost completely depleted. Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment. RESULTS: No per- or postoperative complications were noted. Infiltrates, hemorrhages and macular edema present preoperatively dissolved over a period of six months. The final visual acuity was 1.0 in both eyes. The patients immune system and lung function slowly recovered during the same time period. CONCLUSIONS: The intravitreal ganciclovir implant provides safe and effective therapy against CMV retinitis, and should be considered in patients acquiring the infection after stem cell transplantation.}},
  author       = {{Ghosh, Fredrik and Hansson, Lars-Jörgen and Bynke, Gunnel and Békássy, Albert}},
  issn         = {{1395-3907}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{101--104}},
  publisher    = {{Wiley}},
  series       = {{Acta Ophthalmologica Scandinavica}},
  title        = {{Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantation.}},
  url          = {{https://lup.lub.lu.se/search/files/4639414/623564.pdf}},
  doi          = {{10.1034/j.1600-0420.2002.800121.x}},
  volume       = {{80}},
  year         = {{2002}},
}