Neuropathology of white matter lesions in vascular cognitive impairment.
(2002) In Cerebrovascular Diseases 13 Suppl 2(Suppl 2). p.11-15- Abstract
- The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradient zone of damage towards surrounding normal tissue and may hold over 200 times the volume of an identified focal lesion, the lacunar infarct. Pathogenetically, the focal lesion results from the acute reaction to regional ischemia, while the diffuse white matter lesion represents the adjustment to altered perfusional and physiological conditions... (More)
- The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradient zone of damage towards surrounding normal tissue and may hold over 200 times the volume of an identified focal lesion, the lacunar infarct. Pathogenetically, the focal lesion results from the acute reaction to regional ischemia, while the diffuse white matter lesion represents the adjustment to altered perfusional and physiological conditions within the tissue. Copyright 2002 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/105919
- author
- Englund, Elisabet LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pathology, Brain Infarction/pathology, Brain, Dementia, Brain Ischemia/pathology
- in
- Cerebrovascular Diseases
- volume
- 13 Suppl 2
- issue
- Suppl 2
- pages
- 11 - 15
- publisher
- Karger
- external identifiers
-
- wos:000174794200003
- scopus:0036128625
- ISSN
- 1421-9786
- DOI
- 10.1159/000049144
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 6f8cfa1b-d24b-48a2-9d77-ad3ad409e39d (old id 105919)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11901237&dopt=Abstract
- date added to LUP
- 2016-04-01 12:00:12
- date last changed
- 2022-04-05 08:12:19
@article{6f8cfa1b-d24b-48a2-9d77-ad3ad409e39d, abstract = {{The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes. The spectrum of ischemic white matter lesions histopathologically represents focal and diffuse lesions, the most common form being the combination of both, in varying proportions. In the combined pathology, the diffuse lesion represents a gradient zone of damage towards surrounding normal tissue and may hold over 200 times the volume of an identified focal lesion, the lacunar infarct. Pathogenetically, the focal lesion results from the acute reaction to regional ischemia, while the diffuse white matter lesion represents the adjustment to altered perfusional and physiological conditions within the tissue. Copyright 2002 S. Karger AG, Basel}}, author = {{Englund, Elisabet}}, issn = {{1421-9786}}, keywords = {{Pathology; Brain Infarction/pathology; Brain; Dementia; Brain Ischemia/pathology}}, language = {{eng}}, number = {{Suppl 2}}, pages = {{11--15}}, publisher = {{Karger}}, series = {{Cerebrovascular Diseases}}, title = {{Neuropathology of white matter lesions in vascular cognitive impairment.}}, url = {{http://dx.doi.org/10.1159/000049144}}, doi = {{10.1159/000049144}}, volume = {{13 Suppl 2}}, year = {{2002}}, }