Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.
(2002) In Cancer Research 62(2). p.409-416- Abstract
- Previous in vitro studies have implied that the Wnt-5a gene plays a role as a tumor suppressor. To explore the clinical relevance of this concept, 96 primary invasive breast carcinomas were stained with a novel anti-Wnt-5a antibody. Loss of Wnt-5a protein expression, evident in 44% of the invasive ductal carcinomas (n = 59), was significantly associated with higher histological grade (P = 0.01) and absence of estrogen (P = 0.003) and progesterone (P = 0.02) receptors. By contrast, loss of Wnt-5a protein in 24% of the invasive lobular carcinomas (n = 37) was not significantly related to any of the variables we investigated. The prognostic value of Wnt-5a for metastatic potential was evaluated by analyzing 83 additional invasive primary... (More)
- Previous in vitro studies have implied that the Wnt-5a gene plays a role as a tumor suppressor. To explore the clinical relevance of this concept, 96 primary invasive breast carcinomas were stained with a novel anti-Wnt-5a antibody. Loss of Wnt-5a protein expression, evident in 44% of the invasive ductal carcinomas (n = 59), was significantly associated with higher histological grade (P = 0.01) and absence of estrogen (P = 0.003) and progesterone (P = 0.02) receptors. By contrast, loss of Wnt-5a protein in 24% of the invasive lobular carcinomas (n = 37) was not significantly related to any of the variables we investigated. The prognostic value of Wnt-5a for metastatic potential was evaluated by analyzing 83 additional invasive primary ductal carcinomas from patients with a longer follow-up time. We found that Wnt-5a expression was lost in tumors from 78% of the patients with recurrent disease (n = 32) compared with 35% of the recurrence-free patients (n = 51; P < 0.001), and that recurrence-free survival was significantly shorter in the Wnt-5a-negative group (P < 0.001). In multivariate analyses, loss of Wnt-5a expression proved to be an independent and powerful predictor of recurrence after adjustment for lymph node status and tumor size (hazard ratio = 4.8; P = 0.002). Our results show that loss of Wnt-5a increases the risk of early relapse and death because of recurrent ductal breast cancer, findings that support the notion that this protein retains tumor suppressor function by virtue of its effects on cell adhesion and motility. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106486
- author
- Jönsson, Marzieh ; Sand-Dejmek, Janna LU ; Bendahl, Pär-Ola LU and Andersson, Tommy LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Neoplasm Staging, Breast Neoplasms/genetics/*metabolism/pathology, 80 and over, Carcinoma, Infiltrating Duct/genetics/*metabolism/pathology, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Middle Age, Human, Proto-Oncogene Proteins/*biosynthesis/genetics, Support, Non-U.S. Gov't, Aged, Adult
- in
- Cancer Research
- volume
- 62
- issue
- 2
- pages
- 409 - 416
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- pmid:11809689
- wos:000173488700017
- scopus:0037081290
- ISSN
- 1538-7445
- language
- English
- LU publication?
- yes
- id
- 71644154-c41a-4653-b817-ebb431e25114 (old id 106486)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11809689&dopt=Abstract
- http://cancerres.aacrjournals.org/content/62/2/409.full
- date added to LUP
- 2016-04-01 16:49:09
- date last changed
- 2022-05-08 20:52:18
@article{71644154-c41a-4653-b817-ebb431e25114,
abstract = {{Previous in vitro studies have implied that the Wnt-5a gene plays a role as a tumor suppressor. To explore the clinical relevance of this concept, 96 primary invasive breast carcinomas were stained with a novel anti-Wnt-5a antibody. Loss of Wnt-5a protein expression, evident in 44% of the invasive ductal carcinomas (n = 59), was significantly associated with higher histological grade (P = 0.01) and absence of estrogen (P = 0.003) and progesterone (P = 0.02) receptors. By contrast, loss of Wnt-5a protein in 24% of the invasive lobular carcinomas (n = 37) was not significantly related to any of the variables we investigated. The prognostic value of Wnt-5a for metastatic potential was evaluated by analyzing 83 additional invasive primary ductal carcinomas from patients with a longer follow-up time. We found that Wnt-5a expression was lost in tumors from 78% of the patients with recurrent disease (n = 32) compared with 35% of the recurrence-free patients (n = 51; P < 0.001), and that recurrence-free survival was significantly shorter in the Wnt-5a-negative group (P < 0.001). In multivariate analyses, loss of Wnt-5a expression proved to be an independent and powerful predictor of recurrence after adjustment for lymph node status and tumor size (hazard ratio = 4.8; P = 0.002). Our results show that loss of Wnt-5a increases the risk of early relapse and death because of recurrent ductal breast cancer, findings that support the notion that this protein retains tumor suppressor function by virtue of its effects on cell adhesion and motility.}},
author = {{Jönsson, Marzieh and Sand-Dejmek, Janna and Bendahl, Pär-Ola and Andersson, Tommy}},
issn = {{1538-7445}},
keywords = {{Neoplasm Staging; Breast Neoplasms/genetics/*metabolism/pathology; 80 and over; Carcinoma; Infiltrating Duct/genetics/*metabolism/pathology; Disease-Free Survival; Female; Gene Expression Regulation; Neoplastic; Gene Silencing; Middle Age; Human; Proto-Oncogene Proteins/*biosynthesis/genetics; Support; Non-U.S. Gov't; Aged; Adult}},
language = {{eng}},
number = {{2}},
pages = {{409--416}},
publisher = {{American Association for Cancer Research Inc.}},
series = {{Cancer Research}},
title = {{Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11809689&dopt=Abstract}},
volume = {{62}},
year = {{2002}},
}