Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.
(2002) In EMBO Journal 21(16). p.4307-4316- Abstract
- Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation of platelet-derived growth factor-B generates viable mice with extensive inter- and intra-individual variation in the density of pericytes throughout the CNS. We found a strong inverse correlation between pericyte density and the formation of a range of retinal microvascular abnormalities strongly reminiscent of those seen in diabetic humans. Proliferative retinopathy invariably... (More)
- Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation of platelet-derived growth factor-B generates viable mice with extensive inter- and intra-individual variation in the density of pericytes throughout the CNS. We found a strong inverse correlation between pericyte density and the formation of a range of retinal microvascular abnormalities strongly reminiscent of those seen in diabetic humans. Proliferative retinopathy invariably developed when pericyte density was <50% of normal. Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/109822
- author
- Enge, Maria ; Bjarnegård, Mattias ; Gerhardt, Holger ; Gustafsson, Erika LU ; Kalén, Mattias ; Asker, Noomi ; Hammes, Hans-Peter ; Shani, Moshe ; Fässler, Reinhardt and Betsholtz, Christer
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- EMBO Journal
- volume
- 21
- issue
- 16
- pages
- 4307 - 4316
- publisher
- Oxford University Press
- external identifiers
-
- pmid:12169633
- wos:000177355300011
- scopus:18544366585
- ISSN
- 1460-2075
- DOI
- 10.1093/emboj/cdf418
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 052695b2-447c-49b8-b806-fa1e76f4e5af (old id 109822)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12169633&dopt=Abstract
- date added to LUP
- 2016-04-01 16:35:58
- date last changed
- 2022-03-22 19:42:22
@article{052695b2-447c-49b8-b806-fa1e76f4e5af, abstract = {{Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation of platelet-derived growth factor-B generates viable mice with extensive inter- and intra-individual variation in the density of pericytes throughout the CNS. We found a strong inverse correlation between pericyte density and the formation of a range of retinal microvascular abnormalities strongly reminiscent of those seen in diabetic humans. Proliferative retinopathy invariably developed when pericyte density was <50% of normal. Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy.}}, author = {{Enge, Maria and Bjarnegård, Mattias and Gerhardt, Holger and Gustafsson, Erika and Kalén, Mattias and Asker, Noomi and Hammes, Hans-Peter and Shani, Moshe and Fässler, Reinhardt and Betsholtz, Christer}}, issn = {{1460-2075}}, language = {{eng}}, number = {{16}}, pages = {{4307--4316}}, publisher = {{Oxford University Press}}, series = {{EMBO Journal}}, title = {{Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.}}, url = {{http://dx.doi.org/10.1093/emboj/cdf418}}, doi = {{10.1093/emboj/cdf418}}, volume = {{21}}, year = {{2002}}, }