Regulation of mitogen-induced lymphocyte DNA synthesis by human interferon of different origins
(1978) In Cellular Immunology 35(1). p.15-24- Abstract
- Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obtained for fibroblast and leukocyte interferons. The effect of interferon was apparently exerted during early stages of the lymphocyte cell cycle. There was no inhibitory effect of interferon if the lymphocytes were washed with medium before being exposed to mitogen. Interferon increased the binding of radiolabeled mitogens to cells. The results... (More)
- Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obtained for fibroblast and leukocyte interferons. The effect of interferon was apparently exerted during early stages of the lymphocyte cell cycle. There was no inhibitory effect of interferon if the lymphocytes were washed with medium before being exposed to mitogen. Interferon increased the binding of radiolabeled mitogens to cells. The results suggest that the immunological effects of interferon are consequences of actions on lymphoid cells. Fibroblast and leukocyte interferons seem to have different modes of action, or to bind differently to target cells. Possible mechanisms for the suppressive and enhancing effects of interferons on lymphoid cells are discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102688
- author
- Miörner, Håkan LU ; Landström, Lars-Erik ; Larner, Ebba ; Larsson, Inger ; Lundgren, Erik and Strannegård, Örjan
- organization
- publishing date
- 1978
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cellular Immunology
- volume
- 35
- issue
- 1
- pages
- 15 - 24
- publisher
- Elsevier
- external identifiers
-
- pmid:620425
- scopus:0017887966
- ISSN
- 0008-8749
- DOI
- 10.1016/0008-8749(78)90122-3
- language
- English
- LU publication?
- yes
- id
- be3879ba-25c6-419d-b85d-ea306e3e222a (old id 1102688)
- date added to LUP
- 2016-04-01 16:34:01
- date last changed
- 2021-01-03 05:15:41
@article{be3879ba-25c6-419d-b85d-ea306e3e222a,
abstract = {{Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obtained for fibroblast and leukocyte interferons. The effect of interferon was apparently exerted during early stages of the lymphocyte cell cycle. There was no inhibitory effect of interferon if the lymphocytes were washed with medium before being exposed to mitogen. Interferon increased the binding of radiolabeled mitogens to cells. The results suggest that the immunological effects of interferon are consequences of actions on lymphoid cells. Fibroblast and leukocyte interferons seem to have different modes of action, or to bind differently to target cells. Possible mechanisms for the suppressive and enhancing effects of interferons on lymphoid cells are discussed.}},
author = {{Miörner, Håkan and Landström, Lars-Erik and Larner, Ebba and Larsson, Inger and Lundgren, Erik and Strannegård, Örjan}},
issn = {{0008-8749}},
language = {{eng}},
number = {{1}},
pages = {{15--24}},
publisher = {{Elsevier}},
series = {{Cellular Immunology}},
title = {{Regulation of mitogen-induced lymphocyte DNA synthesis by human interferon of different origins}},
url = {{http://dx.doi.org/10.1016/0008-8749(78)90122-3}},
doi = {{10.1016/0008-8749(78)90122-3}},
volume = {{35}},
year = {{1978}},
}