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The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat

Holmin, T ; Agardh, Carl-David LU ; Alinder, G ; Herlin, P and Hultberg, B (1983) In European Journal of Clinical Investigation 13(3). p.215-220
Abstract
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the... (More)
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
labile phosphates, Hepatectom, amino acids, microsurgery, rat
in
European Journal of Clinical Investigation
volume
13
issue
3
pages
215 - 220
publisher
Wiley-Blackwell
external identifiers
  • pmid:6135613
  • scopus:0020615354
ISSN
0014-2972
DOI
10.1111/j.1365-2362.1983.tb00090.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510)
id
e669f067-e851-434d-9ca5-59b5f41368d6 (old id 1103058)
date added to LUP
2016-04-01 12:15:02
date last changed
2021-01-03 11:05:39
@article{e669f067-e851-434d-9ca5-59b5f41368d6,
  abstract     = {{The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state.}},
  author       = {{Holmin, T and Agardh, Carl-David and Alinder, G and Herlin, P and Hultberg, B}},
  issn         = {{0014-2972}},
  keywords     = {{labile phosphates; Hepatectom; amino acids; microsurgery; rat}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{215--220}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Clinical Investigation}},
  title        = {{The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2362.1983.tb00090.x}},
  doi          = {{10.1111/j.1365-2362.1983.tb00090.x}},
  volume       = {{13}},
  year         = {{1983}},
}