Distribution of different fibre types in human skeletal muscles: a method for the detection of neurogenic disorders
(1987) In IMA Journal of Mathematics Applied in Medicine and Biology 4(1). p.81-91- Abstract
- Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The... (More)
- Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The negative binomial distribution is shown to fit closely, where the parameters can be expressed in terms of the number of fibres and the fibre type proportion in a sample area. This result permits the calculation of significance levels for a sample area and the combination of information in several sample areas. Finally, the method is applied to whole cross-sections of 24 male human autopsied muscles. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103946
- author
- Downham, D Y ; Wilson, B C ; Lexell, Jan LU and Sjöstrom, Michael
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- IMA Journal of Mathematics Applied in Medicine and Biology
- volume
- 4
- issue
- 1
- pages
- 81 - 91
- publisher
- Oxford University Press
- external identifiers
-
- pmid:3503089
- scopus:77957188193
- ISSN
- 0265-0746
- DOI
- 10.1093/imammb/4.1.81
- language
- English
- LU publication?
- no
- id
- 45c18fad-376e-4994-a3e5-8e07a84a72c2 (old id 1103946)
- date added to LUP
- 2016-04-01 15:49:25
- date last changed
- 2021-01-03 09:20:41
@article{45c18fad-376e-4994-a3e5-8e07a84a72c2,
abstract = {{Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The negative binomial distribution is shown to fit closely, where the parameters can be expressed in terms of the number of fibres and the fibre type proportion in a sample area. This result permits the calculation of significance levels for a sample area and the combination of information in several sample areas. Finally, the method is applied to whole cross-sections of 24 male human autopsied muscles.}},
author = {{Downham, D Y and Wilson, B C and Lexell, Jan and Sjöstrom, Michael}},
issn = {{0265-0746}},
language = {{eng}},
number = {{1}},
pages = {{81--91}},
publisher = {{Oxford University Press}},
series = {{IMA Journal of Mathematics Applied in Medicine and Biology}},
title = {{Distribution of different fibre types in human skeletal muscles: a method for the detection of neurogenic disorders}},
url = {{http://dx.doi.org/10.1093/imammb/4.1.81}},
doi = {{10.1093/imammb/4.1.81}},
volume = {{4}},
year = {{1987}},
}