Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.
Lundwall, Åke LU ; Bjartell, Anders LU ; Ceder, Yvonne LU
and Malm, Johan
LU
(2002)
In Molecular Human Reproduction
8(9).
p.805-810
- Abstract
- Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen. The primary source of these proteins is the seminal vesicles and, apart from a small production of SgII in epididymis, they have not been detected in other tissues. In this report, we have re-examined the distribution of SgI and SgII transcripts and protein by RT-PCR and immunohistochemistry. Both SgI and SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI, whereas in kidney and testis, SgII... (More)
- Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen. The primary source of these proteins is the seminal vesicles and, apart from a small production of SgII in epididymis, they have not been detected in other tissues. In this report, we have re-examined the distribution of SgI and SgII transcripts and protein by RT-PCR and immunohistochemistry. Both SgI and SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI, whereas in kidney and testis, SgII transcripts were predominant. By immunohistochemistry, the basal cell layer of the secretory epithelium in prostate, trachea and bronchi was stained by antibodies recognizing both SgI and SgII. This is in contrast to the seminal vesicle and vas deferens, where the luminal cells were stained. The staining of skeletal muscle cells and a few scattered cells in the central nervous system suggests that semenogelin expression is not restricted to epithelial cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/110449
- author
- Lundwall, Åke
LU
; Bjartell, Anders
LU
; Ceder, Yvonne
LU
and Malm, Johan
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Human Reproduction
- volume
- 8
- issue
- 9
- pages
- 805 - 810
- publisher
- Oxford University Press
- external identifiers
-
- pmid:12200457
- wos:000177970900003
- scopus:0036713173
- ISSN
- 1460-2407
- language
- English
- LU publication?
- yes
- id
- 209d5953-85b3-4d8d-ab27-91079ccd946a (old id 110449)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12200457&dopt=Abstract
- date added to LUP
- 2016-04-01 11:37:57
- date last changed
- 2022-05-19 02:19:59
@article{209d5953-85b3-4d8d-ab27-91079ccd946a,
abstract = {{Semenogelin I (SgI) and semenogelin II (SgII) are the dominating protein components of the coagulum formed by freshly ejaculated human semen. The primary source of these proteins is the seminal vesicles and, apart from a small production of SgII in epididymis, they have not been detected in other tissues. In this report, we have re-examined the distribution of SgI and SgII transcripts and protein by RT-PCR and immunohistochemistry. Both SgI and SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI, whereas in kidney and testis, SgII transcripts were predominant. By immunohistochemistry, the basal cell layer of the secretory epithelium in prostate, trachea and bronchi was stained by antibodies recognizing both SgI and SgII. This is in contrast to the seminal vesicle and vas deferens, where the luminal cells were stained. The staining of skeletal muscle cells and a few scattered cells in the central nervous system suggests that semenogelin expression is not restricted to epithelial cells.}},
author = {{Lundwall, Åke and Bjartell, Anders and Ceder, Yvonne and Malm, Johan}},
issn = {{1460-2407}},
language = {{eng}},
number = {{9}},
pages = {{805--810}},
publisher = {{Oxford University Press}},
series = {{Molecular Human Reproduction}},
title = {{Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12200457&dopt=Abstract}},
volume = {{8}},
year = {{2002}},
}