Cerebroelectrical depression following surfactant treatment in preterm neonates
(1992) In Pediatrics 89(4 Pt 1). p.643-647- Abstract
- During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P... (More)
- During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P greater than .05), but they had a significantly lower mean arterial blood pressure after surfactant instillation (P less than .05). No other differences were found between neonates in whom intraventricular hemorrhage developed and those without intraventricular hemorrhage. The present findings demonstrate that an acute cerebral dysfunction may occur after surfactant instillation. In some vulnerable neonates with arterial hypotension and severe pulmonary immaturity, the fall in mean arterial blood pressure may increase the risk of cerebral complications and could be related to an unchanged rate of intraventricular hemorrhage after surfactant treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106166
- author
- Hellström-Westas, Lena LU ; Bell, A H ; Skov, L ; Greisen, G and Svenningsen, N W
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatrics
- volume
- 89
- issue
- 4 Pt 1
- pages
- 643 - 647
- publisher
- American Academy of Pediatrics
- external identifiers
-
- pmid:1557244
- scopus:0026528559
- ISSN
- 1098-4275
- language
- English
- LU publication?
- yes
- id
- c3821e25-4a8e-4783-8e23-4cc31c082d38 (old id 1106166)
- alternative location
- http://pediatrics.aappublications.org/cgi/content/abstract/89/4/643
- date added to LUP
- 2016-04-01 16:05:38
- date last changed
- 2021-08-29 04:16:34
@article{c3821e25-4a8e-4783-8e23-4cc31c082d38,
abstract = {{During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P greater than .05), but they had a significantly lower mean arterial blood pressure after surfactant instillation (P less than .05). No other differences were found between neonates in whom intraventricular hemorrhage developed and those without intraventricular hemorrhage. The present findings demonstrate that an acute cerebral dysfunction may occur after surfactant instillation. In some vulnerable neonates with arterial hypotension and severe pulmonary immaturity, the fall in mean arterial blood pressure may increase the risk of cerebral complications and could be related to an unchanged rate of intraventricular hemorrhage after surfactant treatment.}},
author = {{Hellström-Westas, Lena and Bell, A H and Skov, L and Greisen, G and Svenningsen, N W}},
issn = {{1098-4275}},
language = {{eng}},
number = {{4 Pt 1}},
pages = {{643--647}},
publisher = {{American Academy of Pediatrics}},
series = {{Pediatrics}},
title = {{Cerebroelectrical depression following surfactant treatment in preterm neonates}},
url = {{http://pediatrics.aappublications.org/cgi/content/abstract/89/4/643}},
volume = {{89}},
year = {{1992}},
}