Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction
(1992) In Cancer Letters 62(1). p.83-86- Abstract
- Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106223
- author
- Nannmark, U ; Sennerby, L ; Bjursten, Lars Magnus LU ; Skolnik, G and Bagge, U
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- lodgement, phagocytes, tumour cells, liver, serotonin (5-HT)
- in
- Cancer Letters
- volume
- 62
- issue
- 1
- pages
- 83 - 86
- publisher
- Elsevier
- external identifiers
-
- pmid:1540935
- scopus:0026570929
- ISSN
- 1872-7980
- DOI
- 10.1016/0304-3835(92)90202-7
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910)
- id
- e3a26af3-e67a-4315-b05c-f145dad4eaaf (old id 1106223)
- date added to LUP
- 2016-04-01 15:55:12
- date last changed
- 2021-03-28 06:01:13
@article{e3a26af3-e67a-4315-b05c-f145dad4eaaf, abstract = {{Intraportal tumour cell (TC) injection activates platelets which release serotonin (5-HT). Thrombocytopenia or 5-HT blockade decrease the hepatic lodgement of the injected TCs. A hypothetical explanation of this is 5-HT inhibition of TC killing by phagocytes (e.g. leukocytes and Kupffer cells). In this study, leukocyte phagocytosis was analysed by a chemiluminescence technique at different 5-HT concentrations. Significant inhibition of phagocytosis occurred at 5-HT concentrations of 10(-4) M to 10(-8) M, with maximum inhibition at 10(-4) M. Comparable concentrations of 5-HT may be found locally in the liver during TC infusion, supporting the hypothesis that 5-HT has an inhibitory effect on phagocyte-mediated TC killing.}}, author = {{Nannmark, U and Sennerby, L and Bjursten, Lars Magnus and Skolnik, G and Bagge, U}}, issn = {{1872-7980}}, keywords = {{lodgement; phagocytes; tumour cells; liver; serotonin (5-HT)}}, language = {{eng}}, number = {{1}}, pages = {{83--86}}, publisher = {{Elsevier}}, series = {{Cancer Letters}}, title = {{Inhibition of leukocyte phagocytosis by serotonin and its possible role in tumor cell destruction}}, url = {{http://dx.doi.org/10.1016/0304-3835(92)90202-7}}, doi = {{10.1016/0304-3835(92)90202-7}}, volume = {{62}}, year = {{1992}}, }