Quantitative morphology of stimulation-induced damage in rabbit fast-twitch skeletal muscles
(1992) In Cell and Tissue Research 269(2). p.195-204- Abstract
- The purpose of this study was to examine the contention that stimulation-induced damage, resulting in degeneration with subsequent regeneration, plays a major role in the transformation of fibre type brought about by chronic electrical stimulation. Data from histological and histochemical sections of 9-day-stimulated rabbit fast-twitch muscles were analysed with multivariate statistical techniques. Fibre degeneration and regeneration varied non-systematically between sample areas at any given cross-sectional level. In the extensor digitorum longus muscle, but not in the tibialis anterior, there was more degeneration in proximal than in distal portions of the muscle. The extensor digitorum longus muscle consistently showed more degeneration... (More)
- The purpose of this study was to examine the contention that stimulation-induced damage, resulting in degeneration with subsequent regeneration, plays a major role in the transformation of fibre type brought about by chronic electrical stimulation. Data from histological and histochemical sections of 9-day-stimulated rabbit fast-twitch muscles were analysed with multivariate statistical techniques. Fibre degeneration and regeneration varied non-systematically between sample areas at any given cross-sectional level. In the extensor digitorum longus muscle, but not in the tibialis anterior, there was more degeneration in proximal than in distal portions of the muscle. The extensor digitorum longus muscle consistently showed more degeneration than the tibialis anterior muscle. Degeneration was less extensive for an intermittent pattern of stimulation that delivered half the aggregate number of impulses of continuous stimulation. Degeneration and regeneration varied markedly between individual rabbits in each of the groups. Sections that revealed the most degeneration and regeneration also had more fibres that reacted positively with an anti-neonatal antibody. Rigorous analysis of different sources of variation has helped to explain apparent conflicts in the literature. The incidence of muscle fibre damage in the stimulated tibialis anterior muscle is low, showing that the contribution of degenerative-regenerative phenomena to fibre type conversion in this muscle is insignificant. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106716
- author
- Lexell, Jan LU ; Jarvis, Jonathan ; Downham, David and Salmons, Stanley
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Histochemistry, Degeneration, Immunohistochemistry, Morphometry, Muscle, Stimulation, chronic, Rabbit
- in
- Cell and Tissue Research
- volume
- 269
- issue
- 2
- pages
- 195 - 204
- publisher
- Springer
- external identifiers
-
- pmid:1423488
- scopus:0026741851
- ISSN
- 1432-0878
- DOI
- 10.1007/BF00319609
- language
- English
- LU publication?
- no
- id
- c90f0b2e-d34c-4241-9bb5-b32f9a6b8dda (old id 1106716)
- date added to LUP
- 2016-04-01 12:35:59
- date last changed
- 2021-01-03 08:16:03
@article{c90f0b2e-d34c-4241-9bb5-b32f9a6b8dda,
abstract = {{The purpose of this study was to examine the contention that stimulation-induced damage, resulting in degeneration with subsequent regeneration, plays a major role in the transformation of fibre type brought about by chronic electrical stimulation. Data from histological and histochemical sections of 9-day-stimulated rabbit fast-twitch muscles were analysed with multivariate statistical techniques. Fibre degeneration and regeneration varied non-systematically between sample areas at any given cross-sectional level. In the extensor digitorum longus muscle, but not in the tibialis anterior, there was more degeneration in proximal than in distal portions of the muscle. The extensor digitorum longus muscle consistently showed more degeneration than the tibialis anterior muscle. Degeneration was less extensive for an intermittent pattern of stimulation that delivered half the aggregate number of impulses of continuous stimulation. Degeneration and regeneration varied markedly between individual rabbits in each of the groups. Sections that revealed the most degeneration and regeneration also had more fibres that reacted positively with an anti-neonatal antibody. Rigorous analysis of different sources of variation has helped to explain apparent conflicts in the literature. The incidence of muscle fibre damage in the stimulated tibialis anterior muscle is low, showing that the contribution of degenerative-regenerative phenomena to fibre type conversion in this muscle is insignificant.}},
author = {{Lexell, Jan and Jarvis, Jonathan and Downham, David and Salmons, Stanley}},
issn = {{1432-0878}},
keywords = {{Histochemistry; Degeneration; Immunohistochemistry; Morphometry; Muscle; Stimulation; chronic; Rabbit}},
language = {{eng}},
number = {{2}},
pages = {{195--204}},
publisher = {{Springer}},
series = {{Cell and Tissue Research}},
title = {{Quantitative morphology of stimulation-induced damage in rabbit fast-twitch skeletal muscles}},
url = {{http://dx.doi.org/10.1007/BF00319609}},
doi = {{10.1007/BF00319609}},
volume = {{269}},
year = {{1992}},
}