Hepatitis C virus infection with progression to hepatocellular carcinoma: a report of five prospectively followed patients in Sweden
(1993) In Scandinavian Journal of Infectious Diseases 25(4). p.417-420- Abstract
- Five Swedish patients with chronic hepatitis C were prospectively followed until hepatocellular carcinoma (HCC) developed. Hepatitis C virus (HCV) antibodies were analysed by a second generation anti-HCV ELISA and a recombinant immunoblot assay (RIBA-2) and viraemia by detection of serum HCV RNA by polymerase chain reaction. Four patients had post transfusion hepatitis and in one patient the source of infection was unknown. HCC developed after 8 to 23 years of mostly asymptomatic disease and all patients died. Four of them were repeatedly biopsied during follow-up and all had chronic active hepatitis. When HCC was diagnosed, cirrhosis was present in all 5. In 4 patients with available sera, anti-HCV was positive and confirmed with RIBA-2,... (More)
- Five Swedish patients with chronic hepatitis C were prospectively followed until hepatocellular carcinoma (HCC) developed. Hepatitis C virus (HCV) antibodies were analysed by a second generation anti-HCV ELISA and a recombinant immunoblot assay (RIBA-2) and viraemia by detection of serum HCV RNA by polymerase chain reaction. Four patients had post transfusion hepatitis and in one patient the source of infection was unknown. HCC developed after 8 to 23 years of mostly asymptomatic disease and all patients died. Four of them were repeatedly biopsied during follow-up and all had chronic active hepatitis. When HCC was diagnosed, cirrhosis was present in all 5. In 4 patients with available sera, anti-HCV was positive and confirmed with RIBA-2, whereof 2 were reactive only to the c-22 and c-33c epitopes. HCV-RNA was present in all sera when HCC was diagnosed. Thus, after prolonged disease duration these patients were still viraemic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106996
- author
- Wejstål, Rune ; Widell, Anders LU and Norkrans, Gunnar
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 25
- issue
- 4
- pages
- 417 - 420
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:7504321
- scopus:0027260739
- ISSN
- 1651-1980
- DOI
- 10.3109/00365549309008521
- language
- English
- LU publication?
- yes
- id
- db79d6bc-a06f-40ae-b452-21a15ac02e79 (old id 1106996)
- date added to LUP
- 2016-04-01 16:14:41
- date last changed
- 2021-01-03 04:45:59
@article{db79d6bc-a06f-40ae-b452-21a15ac02e79, abstract = {{Five Swedish patients with chronic hepatitis C were prospectively followed until hepatocellular carcinoma (HCC) developed. Hepatitis C virus (HCV) antibodies were analysed by a second generation anti-HCV ELISA and a recombinant immunoblot assay (RIBA-2) and viraemia by detection of serum HCV RNA by polymerase chain reaction. Four patients had post transfusion hepatitis and in one patient the source of infection was unknown. HCC developed after 8 to 23 years of mostly asymptomatic disease and all patients died. Four of them were repeatedly biopsied during follow-up and all had chronic active hepatitis. When HCC was diagnosed, cirrhosis was present in all 5. In 4 patients with available sera, anti-HCV was positive and confirmed with RIBA-2, whereof 2 were reactive only to the c-22 and c-33c epitopes. HCV-RNA was present in all sera when HCC was diagnosed. Thus, after prolonged disease duration these patients were still viraemic.}}, author = {{Wejstål, Rune and Widell, Anders and Norkrans, Gunnar}}, issn = {{1651-1980}}, language = {{eng}}, number = {{4}}, pages = {{417--420}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{Hepatitis C virus infection with progression to hepatocellular carcinoma: a report of five prospectively followed patients in Sweden}}, url = {{http://dx.doi.org/10.3109/00365549309008521}}, doi = {{10.3109/00365549309008521}}, volume = {{25}}, year = {{1993}}, }